Association of Number of Oral bacteria with Ventilator-Associated Pneumonia and Delirium in Patients in the Intensive Care Unit.

IF 3 3区医学 Q2 CRITICAL CARE MEDICINE

Journal of Intensive Care Medicine Pub Date : 2025-02-27 DOI:10.1177/08850666251320924

Chika Arimizu, Tomohiko Akahoshi, Teppei Jinno, Michiko Furuta, Ayako Ohashi, Shinnosuke Takamori, Naohisa Wada

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引用次数: 0

Abstract

Objectives: Ventilator-associated pneumonia (VAP) and delirium are major complications among patients in the intensive care unit (ICU). The impact of oral bacterial count on these conditions is not well understood. This study aimed to explore the association between oral bacterial load and the incidence of VAP and delirium in ICU patients.

Methods: In this single-center longitudinal study, 130 patients admitted to the ICU from September 2022 to May 2023 were included. Oral bacteria counts on the tongue were quantified, and assessments of oral health using the Oral Health Assessment Tool (OHAT) and oral moisture levels were also conducted. We examined the associations between oral bacterial count, OHAT scores, and oral moisture with the incidence of VAP and delirium.

Results: The incidence rates of VAP and delirium were 31.4% and 35.4%, respectively. Patients with a high oral bacterial load (≥5.0 × 10⁷ CFU/mL) at ICU admission had a higher likelihood of developing VAP (odds ratio [OR] 7.43, 95% confidence interval [CI] 1.68-32.87) and delirium (OR 3.30, 95% CI 1.04-10.44) compared with those with lower bacterial counts (<1.0 × 10⁷ CFU/mL). No significant associations were found between OHAT scores and oral moisture and the occurrence of VAP or delirium.

Conclusion: A higher oral bacterial count at ICU admission was associated with increased incidences of VAP and delirium.

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重症监护病房患者口腔细菌数量与呼吸机相关性肺炎和谵妄的关系。

目的：呼吸机相关性肺炎（VAP）和谵妄是重症监护病房（ICU）患者的主要并发症。口腔细菌计数对这些疾病的影响尚不清楚。本研究旨在探讨ICU患者口腔细菌负荷与VAP和谵妄发生率的关系。方法：在这项单中心纵向研究中，纳入了2022年9月至2023年5月在ICU住院的130例患者。对舌头上的口腔细菌计数进行量化，并使用口腔健康评估工具（OHAT）和口腔水分水平对口腔健康进行评估。我们研究了口腔细菌计数、OHAT评分和口腔湿度与VAP和谵妄发生率之间的关系。结果：VAP和谵妄的发生率分别为31.4%和35.4%。入院时口腔细菌负荷高（≥5.0 × 107 CFU/mL）的患者发生VAP（优势比[OR] 7.43, 95%可信区间[CI] 1.68-32.87）和谵妄（OR 3.30, 95% CI 1.04-10.44）的可能性高于细菌计数较低（7 CFU/mL）的患者。OHAT评分和口腔湿度与VAP或谵妄的发生之间没有明显的关联。结论：ICU入院时较高的口腔细菌计数与VAP和谵妄的发生率增加有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Intensive Care Medicine CRITICAL CARE MEDICINE-

CiteScore

7.60

自引率

3.20%

发文量

107

期刊介绍： Journal of Intensive Care Medicine (JIC) is a peer-reviewed bi-monthly journal offering medical and surgical clinicians in adult and pediatric intensive care state-of-the-art, broad-based analytic reviews and updates, original articles, reports of large clinical series, techniques and procedures, topic-specific electronic resources, book reviews, and editorials on all aspects of intensive/critical/coronary care.