Neuropathic pain management: a focused review of current treatments and novel data from main ongoing clinical trials.

IF 4.9 2区医学 Q1 PHARMACOLOGY & PHARMACY

Expert opinion on investigational drugs Pub Date : 2025-04-01 Epub Date: 2025-03-02 DOI:10.1080/13543784.2025.2473692

Nikola Andrejic, Ivo Božovic, Hadi Moradi, Rojin Tataei, Nebojsa Nick Knezevic

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引用次数: 0

Abstract

Introduction: Neuropathic pain (NP) remains a significant challenge in clinical practice, requiring a sophisticated pharmacotherapeutic strategy for effective symptom management. This review provides a comprehensive analysis of the current pharmacological treatments for NP, focusing on their efficacy, mechanism of action, and therapeutic potential. Additionally, it evaluates ongoing clinical trials investigating novel drugs and therapeutic approaches, highlighting emerging trends and future directions in NP management.

Areas covered: This review examines first- to third-line therapeutic modalities for NP, critically analyzing their efficacy, safety profiles, and clinical applications. It also includes an overview of ongoing clinical trials exploring innovative pharmacological therapies. A thorough literature review was conducted using the MEDLINE database without temporal limitations, offering a detailed assessment of established and emerging treatments.

Expert opinion: While current pharmacological options offer significant symptom relief, their overall effectiveness in managing NP remains limited, highlighting the need for further therapeutic advancements. Staying informed about emerging therapies and clinical trials is vital to enhancing patient care and quality of life. The future of NP management lies in optimizing individualized treatment strategies, refining therapeutic approaches, and fostering interdisciplinary collaboration. Close monitoring of outcomes and continued research are essential for advancing understanding and improving the precision of NP therapies.

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神经性疼痛管理：当前治疗方法和主要正在进行的临床试验的新数据的集中回顾。

神经性疼痛（NP）在临床实践中仍然是一个重大挑战，需要一个复杂的药物治疗策略来有效的症状管理。本文综述了目前NP的药理治疗方法，重点介绍了其疗效、作用机制和治疗潜力。此外，它还评估了正在进行的研究新药和治疗方法的临床试验，强调了NP管理的新兴趋势和未来方向。涵盖领域：本综述考察了NP的一线到三线治疗方式，批判性地分析了它们的疗效、安全性和临床应用。它还包括正在进行的临床试验探索创新的药理学疗法的概述。使用MEDLINE数据库进行了全面的文献回顾，没有时间限制，提供了对现有和新兴治疗方法的详细评估。专家意见：虽然目前的药物选择提供了显著的症状缓解，但它们在管理NP方面的总体有效性仍然有限，强调需要进一步的治疗进展。了解新出现的治疗方法和临床试验对于提高患者护理和生活质量至关重要。NP管理的未来在于优化个性化治疗策略，改进治疗方法，促进跨学科合作。密切监测结果和持续的研究对于促进理解和提高NP治疗的准确性至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert opinion on investigational drugs 医学-药学

CiteScore

10.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Expert Opinion on Investigational Drugs (ISSN 1354-3784 [print], 1744-7658 [electronic]) is a MEDLINE-indexed, peer-reviewed, international journal publishing review articles and original papers on drugs in preclinical and early stage clinical development, providing expert opinion on the scope for future development. The Editors welcome: Reviews covering preclinical through to Phase II data on drugs or drug classes for specific indications, and their potential impact on future treatment strategies Drug Evaluations reviewing the clinical and pharmacological data on a particular drug Original Research papers reporting the results of clinical investigations on agents that are in Phase I and II clinical trials The audience consists of scientists, managers and decision-makers in the pharmaceutical industry, and others closely involved in R&D.