Influence of infection control for COVID-19 on nutrition in relatively healthy Japanese HD patients: a retrospective observational study.

IF 2.2 4区医学 Q2 UROLOGY & NEPHROLOGY

Clinical and Experimental Nephrology Pub Date : 2025-02-28 DOI:10.1007/s10157-025-02638-3

Yuki Chiba, Ryotaro Takahashi, Rui Makino, Mai Yoshida, Koji Okamoto, Tasuku Nagasawa, Ichiro Kato, Sadatoshi Ito, Tetsuhiro Tanaka, Mariko Miyazaki

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引用次数: 0

Abstract

Background: Infection control for the novel coronavirus disease 2019 (COVID-19) has been linked to decreased physical activity and nutritional deterioration in the general population; however, the influence on hemodialysis (HD) patients is not well discussed.

Methods: This multicenter retrospective study utilized the Geriatric Nutritional Risk Index (GNRI), Survival Index, and Nutritional Risk Index for Japanese HD patients (NRI-JH) to assess nutritional status and body composition over five observation periods. The primary endpoint was the body fluid removal rate (%) pre- and post-HD, whereas secondary endpoints included changes in GNRI, SI, body composition, and differences in NRI-JH.

Results: We enrolled 139 HD patients in three facilities. The results showed a decrease in GNRI score, which indicates nutritional deterioration, between February 2020 and August 2020 (96.8 (93.2-98.9) vs. 93.8 (90.8-97.6)) (P = 0.0005). Multivariable analysis revealed that nutritional deterioration was associated with higher C-reactive protein and lower hemoglobin levels (P = 0.0004 and P = 0.0010, respectively), which were more noticeable in the urban facility. Furthermore, nutritional deterioration was linked to a decrease in soft lean and somatic cell mass and an increase in body fat mass, suggesting reduced physical activity.

Conclusions: Nutritional deterioration was observed shortly after the first COVID-19 outbreak, suggesting an association with decreased physical activity.

查看原文本刊更多论文

COVID-19感染控制对相对健康的日本血液透析患者营养状况的影响：一项回顾性观察研究。

背景：2019年新型冠状病毒病（COVID-19）的感染控制与普通人群体力活动减少和营养恶化有关；然而，对血液透析（HD）患者的影响尚未得到很好的讨论。方法：本多中心回顾性研究利用日本HD患者的老年营养风险指数（GNRI）、生存指数和营养风险指数（NRI-JH）评估5个观察期的营养状况和身体成分。主要终点是hd前后的体液去除率（%），而次要终点包括GNRI、SI、身体成分的变化以及NRI-JH的差异。结果：我们在三个机构招募了139名HD患者。结果显示，在2020年2月至2020年8月期间，GNRI评分下降（96.8（93.2-98.9）比93.8 (90.8-97.6)）（P = 0.0005）。多变量分析显示，营养恶化与较高的c反应蛋白和较低的血红蛋白水平相关（P = 0.0004和P = 0.0010），这在城市设施中更为明显。此外，营养恶化与软瘦肉细胞和体细胞质量的减少以及体脂肪质量的增加有关，这表明体力活动减少。结论：在首次COVID-19爆发后不久就观察到营养恶化，这表明营养恶化与身体活动减少有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Experimental Nephrology UROLOGY & NEPHROLOGY-

CiteScore

4.10

自引率

4.30%

发文量

135

审稿时长

4-8 weeks

期刊介绍： Clinical and Experimental Nephrology is a peer-reviewed monthly journal, officially published by the Japanese Society of Nephrology (JSN) to provide an international forum for the discussion of research and issues relating to the study of nephrology. Out of respect for the founders of the JSN, the title of this journal uses the term “nephrology,” a word created and brought into use with the establishment of the JSN (Japanese Journal of Nephrology, Vol. 2, No. 1, 1960). The journal publishes articles on all aspects of nephrology, including basic, experimental, and clinical research, so as to share the latest research findings and ideas not only with members of the JSN, but with all researchers who wish to contribute to a better understanding of recent advances in nephrology. The journal is unique in that it introduces to an international readership original reports from Japan and also the clinical standards discussed and agreed by JSN.