The association of fasting triglyceride variability with renal dysfunction and proteinuria in medical checkup participants.

IF 2.2 4区医学 Q2 UROLOGY & NEPHROLOGY

Clinical and Experimental Nephrology Pub Date : 2025-02-28 DOI:10.1007/s10157-025-02640-9

Natsumi Matsuoka-Uchiyama, Haruhito A Uchida, Tomohiko Asakawa, Yoshimasa Sakurabu, Katsuyoshi Katayama, Shugo Okamoto, Yasuhiro Onishi, Keiko Tanaka, Hidemi Takeuchi, Rika Takemoto, Ryoko Umebayashi, Jun Wada

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引用次数: 0

Abstract

Background: The association between the variability of triglyceride (TG) and chronic kidney disease (CKD) progression remains unclear. We examined whether intraindividual variability in fasting TG was associated with the exacerbation of CKD.

Methods: We conducted a retrospective and observational study. 18,339 participants, who went through medical checkups and had checked their estimated glomerular filtration rate (eGFR) and semi-quantitative proteinuria by urine dipstick every year since 2017 for 4 years were registered. Variability in fasting TG was determined using the standard deviation (SD), and maximum minus minimum difference (MMD) between 2017 and 2021. The primary end point for the analysis of eGFR decline was eGFR < 60 mL/min/1.73 m². The secondary end point for the analysis of proteinuria was the incidence of proteinuria ≥ ( ±) by urine dipstick.

Results: The renal survival was lower in the higher-SD, and higher-MMD groups than in the lower-SD, and lower-MMD groups, respectively (log-rank test p < 0.001, and < 0.001, respectively). Lower SD and lower MMD were significantly associated with renal survival in the adjusted model (hazard ratio (HR), 1.12; 95% confidence intervals (CI), 1.04-1.21, and HR, 1.13; 95% CI 1.05-1.23, respectively). The non-incidence of proteinuria was lower in the higher-SD, and higher-MMD groups than in the lower-SD, and lower-MMD groups, respectively (log-rank test p < 0.001 and < 0.001, respectively).

Conclusion: Fasting TG variability was associated with CKD progression in participants who went through medical checkups.

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体检参与者空腹甘油三酯变异性与肾功能和蛋白尿的关系

背景：甘油三酯（TG）变异性与慢性肾脏疾病（CKD）进展之间的关系尚不清楚。我们研究了空腹TG的个体变异性是否与CKD的恶化有关。方法：采用回顾性观察性研究。18339名参与者接受了医学检查，并自2017年以来每年通过尿试纸检查他们的肾小球滤过率（eGFR）和半定量蛋白尿，持续4年。2017年至2021年间，空腹TG的变异性使用标准差（SD）和最大-最小差（MMD）来确定。分析eGFR下降的主要终点是eGFR 2。蛋白尿分析的次要终点为蛋白尿发生率≥（±）。结果：高sd组和高mmd组的肾脏存活率分别低于低sd组和低mmd组（log-rank检验p）。结论：在接受体检的参与者中，空腹TG变异性与CKD进展有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Experimental Nephrology UROLOGY & NEPHROLOGY-

CiteScore

4.10

自引率

4.30%

发文量

135

审稿时长

4-8 weeks

期刊介绍： Clinical and Experimental Nephrology is a peer-reviewed monthly journal, officially published by the Japanese Society of Nephrology (JSN) to provide an international forum for the discussion of research and issues relating to the study of nephrology. Out of respect for the founders of the JSN, the title of this journal uses the term “nephrology,” a word created and brought into use with the establishment of the JSN (Japanese Journal of Nephrology, Vol. 2, No. 1, 1960). The journal publishes articles on all aspects of nephrology, including basic, experimental, and clinical research, so as to share the latest research findings and ideas not only with members of the JSN, but with all researchers who wish to contribute to a better understanding of recent advances in nephrology. The journal is unique in that it introduces to an international readership original reports from Japan and also the clinical standards discussed and agreed by JSN.