Biomarkers to predict 30-day mortality in patients with Fournier's gangrene disease: a retrospective study.

IF 1.5 4区医学 Q3 SURGERY

ANZ Journal of Surgery Pub Date : 2025-02-28 DOI:10.1111/ans.70025

Akile Zengin, Gokberk Alagas, Yusuf Murat Bag, Ahmet Murat Sendil, Ahmet Umit Cebeci, Elif Gundogdu, Yavuz Selim Angin, Mehmet Kılıc, Murat Ulas

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引用次数: 0

Abstract

Aim: Fournier gangrene disease (FGD) is a condition that requires emergent surgery due to its high risk of mortality. The use of biomarkers to predict outcomes after surgery for patients with FGD may be critical, as they assist in tailoring treatment approaches to individual needs. Our aim in our study is to investigate the presence of simple and easily accessible biochemical markers that can be used to predict early mortality.

Methods: The medical records of 100 patients diagnosed with FGD at our hospital between January 2015 and December 2023 were retrospectively reviewed. Clinical and laboratory variables were assessed, and predictive factors for mortality were analyzed using multivariate logistic regression.

Results: Demographics and perioperative clinical data of the whole study group, and subgroups according to the mortality status are evaluated. CRP was found to be independent predictor for 30-day mortality in FGD. In ROC curve analysis provided a cutoff value of 121.3 mg/L for CRP which was significantly associated with 30-day mortality for FGD.

Conclusion: Preoperative CRP ≥ 121.3 mg/L value could be predict 30-day mortality in patients diagnosed with FGD.

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目的：富尼埃坏疽病（Fournier gangrene disease，FGD）是一种需要紧急手术治疗的疾病，因为其死亡率很高。使用生物标志物来预测 FGD 患者手术后的预后可能至关重要，因为这些标志物有助于根据个体需求调整治疗方法。我们的研究旨在调查是否存在简单易得的生化标志物，可用于预测早期死亡率：方法：我们回顾性审查了本医院在 2015 年 1 月至 2023 年 12 月期间确诊的 100 例肺结核患者的病历。评估了临床和实验室变量，并使用多变量逻辑回归分析了死亡率的预测因素：结果：评估了整个研究组的人口统计学和围手术期临床数据，以及根据死亡率状况划分的亚组。发现 CRP 是 FGD 30 天死亡率的独立预测因素。在ROC曲线分析中，CRP的临界值为121.3 mg/L，这与肺结核患者的30天死亡率显著相关：结论：术前 CRP 值≥ 121.3 mg/L 可预测 FGD 患者的 30 天死亡率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ANZ Journal of Surgery 医学-外科

CiteScore

2.50

自引率

11.80%

发文量

720

审稿时长

2 months

期刊介绍： ANZ Journal of Surgery is published by Wiley on behalf of the Royal Australasian College of Surgeons to provide a medium for the publication of peer-reviewed original contributions related to clinical practice and/or research in all fields of surgery and related disciplines. It also provides a programme of continuing education for surgeons. All articles are peer-reviewed by at least two researchers expert in the field of the submitted paper.