Disparities in heart failure deaths among people with diabetes in the United States: 1999-2020.

IF 5.4 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Benjamin Grobman, Arian Mansur, Christine Y Lu
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Abstract

Aims: Heart failure is a leading cause of mortality in the United States, with significant disparities in its burden, particularly among underserved populations. A similar pattern exists for diabetes, but less is known about the mortality impact of these two comorbid conditions. This study aims to examine the risk of death from heart failure among people with diabetes, focusing on socio-demographic disparities.

Materials and methods: We analysed data from the Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research Multiple Cause of Death Database, examining patterns of heart failure deaths in which diabetes was a contributing cause. Our analysis was stratified by socio-demographic variables, including race, ethnicity and geography, and we also explored trends over time.

Results: Between 1999 and 2020, there were 82 617 deaths from heart failure in which diabetes was a contributing cause, with an age-adjusted mortality rate of 32.04 deaths per 1 000 000 individuals. The death rate increased by 2.18% during the study period. Death rates were higher among Black Americans compared with White Americans (age-adjusted mortality rate ratio = 1.51, 95% confidence interval: 1.49-1.53), with disparities growing over time (a 10.75% increase for Black Americans vs. a 1.11% increase for White Americans).

Conclusions: Deaths from comorbid heart failure and diabetes are increasing in the United States, with significant and worsening disparities, particularly among minorities. Urgent action is needed to reduce heart failure mortality among people with diabetes, especially in underserved populations.

美国糖尿病患者心力衰竭死亡率的差异:1999-2020.
目的:在美国,心力衰竭是导致死亡的一个主要原因,其负担差异很大,尤其是在服务不足的人群中。糖尿病也存在类似的情况,但人们对这两种并发症对死亡率的影响知之甚少。本研究旨在探讨糖尿病患者死于心力衰竭的风险,重点关注社会人口差异:我们分析了美国疾病控制和预防中心流行病学研究多死因广泛在线数据数据库中的数据,研究了以糖尿病为诱因的心力衰竭死亡模式。我们的分析按种族、民族和地域等社会人口变量进行了分层,并探讨了随时间变化的趋势:1999年至2020年间,共有82 617人死于心力衰竭,其中糖尿病是诱因之一,经年龄调整后的死亡率为每1 000 000人中有32.04人死亡。在研究期间,死亡率上升了 2.18%。与美国白人相比,美国黑人的死亡率更高(年龄调整后死亡率比值=1.51,95%置信区间:1.49-1.53),而且随着时间的推移,差异也在扩大(美国黑人增加了10.75%,而美国白人增加了1.11%):结论:在美国,因合并心力衰竭和糖尿病而死亡的人数正在增加,尤其是在少数族裔中,差异显著且不断恶化。需要采取紧急行动降低糖尿病患者的心力衰竭死亡率,尤其是在服务不足的人群中。
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来源期刊
Diabetes, Obesity & Metabolism
Diabetes, Obesity & Metabolism 医学-内分泌学与代谢
CiteScore
10.90
自引率
6.90%
发文量
319
审稿时长
3-8 weeks
期刊介绍: Diabetes, Obesity and Metabolism is primarily a journal of clinical and experimental pharmacology and therapeutics covering the interrelated areas of diabetes, obesity and metabolism. The journal prioritises high-quality original research that reports on the effects of new or existing therapies, including dietary, exercise and lifestyle (non-pharmacological) interventions, in any aspect of metabolic and endocrine disease, either in humans or animal and cellular systems. ‘Metabolism’ may relate to lipids, bone and drug metabolism, or broader aspects of endocrine dysfunction. Preclinical pharmacology, pharmacokinetic studies, meta-analyses and those addressing drug safety and tolerability are also highly suitable for publication in this journal. Original research may be published as a main paper or as a research letter.
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