Medication-related osteonecrosis of the jaw in an older patient with multiple myeloma

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Gerodontology Pub Date : 2025-02-28 DOI:10.1111/ger.12758

Larissa Couto de Freitas, Vanessa Silvestre de Aquino Silva, Marta Miyazawa, Carine Ervolino de Oliveira, Felipe Fornias Sperandio, João Adolfo Costa Hanemann

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引用次数: 0

Abstract

Objective

This article reports a case of medication-related osteonecrosis of the jaw (MRONJ) associated with multiple myeloma (MM).

Background

Bisphosphonates (BPs) are constantly used as part of the treatment for MM. The main adverse effects of bisphosphonates are renal insufficiency and medication-related osteonecrosis of the jaw (MRONJ).

Materials and Methods

A 67-year-old female with a previous diagnosis of MM and undergoing current receiving intravenous injections of pamidronate underwent a tooth extraction and subsequently developed MRONJ.

Results

MRONJ was managed with clindamycin, surgical removal of bony sequestrum and curettage. At 3 years of follow-up, the patient was asymptomatic with no clinical changes and panoramic radiography without evidence of recurrence.

Conclusion

Management of patients under antiresorptive drugs who require invasive dental procedures is challenging. Therefore, interprofessional collaboration, especially between the general practitioner and oncologist and/or haematologist, is essential to reach the best clinical approach and reduce the risk of MRONJ.

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来源期刊

Gerodontology 医学-老年医学

CiteScore

4.10

自引率

10.00%

发文量

审稿时长

3-6 weeks

期刊介绍： The ultimate aim of Gerodontology is to improve the quality of life and oral health of older people. The boundaries of most conventional dental specialties must be repeatedly crossed to provide optimal dental care for older people. In addition, management of other health problems impacts on dental care and clinicians need knowledge in these numerous overlapping areas. Bringing together these diverse topics within one journal serves clinicians who are seeking to read and to publish papers across a broad spectrum of specialties. This journal provides the juxtaposition of papers from traditional specialties but which share this patient-centred interest, providing a synergy that serves progress in the subject of gerodontology.