Potential drug exposure risk assessment of analysts in analytical laboratories through fingernail, hair, and atmospheric environment analyses

IF 3.1 3区医学 Q2 CHEMISTRY, ANALYTICAL

Journal of pharmaceutical and biomedical analysis Pub Date : 2025-02-27 DOI:10.1016/j.jpba.2025.116779

Panpan Chen , Wu Wen , Hongxian Yang , Jianmei Wu , Xiaoyu Zheng , Mengxiang Su , Jie Chen

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引用次数: 0

Abstract

Analysts in drug testing laboratories are frequently exposed to drugs as part of their daily work activities. Certain drug components can vaporise and adhere to atmospheric particles. Therefore, the presence of drugs in laboratory settings can affect the health and well-being of the laboratory personnel. This study aimed to highlight possible health consequences of 25 expected drug exposure risks by examining fingernail, hair, and atmospheric environment samples. The results showed that etomidate was detected in the hair samples of eight individuals, with the highest level of 19.73 pg/mg, and no components were detected in the fingernail samples. This indicates that etomidate may adhere to hair but does not significantly affect the human body. An atmospheric particulate sampler was used to collect atmospheric particulate matter and gaseous samples from different laboratory rooms. Methamphetamine, ketamine, etomidate, and other drugs were detected in atmospheric particles and gases. Furthermore, the distribution of these chemicals was evaluated by comparing their concentrations in total suspended particulate matter and gas phase. The development and application of these methods coupled with data analysis, aimed at enhancing the self-protection awareness of laboratory scientists and establish a foundation for future assessments of potential hazards.

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来源期刊

Journal of pharmaceutical and biomedical analysis 医学-分析化学

CiteScore

6.70

自引率

5.90%

发文量

588

审稿时长

37 days

期刊介绍： This journal is an international medium directed towards the needs of academic, clinical, government and industrial analysis by publishing original research reports and critical reviews on pharmaceutical and biomedical analysis. It covers the interdisciplinary aspects of analysis in the pharmaceutical, biomedical and clinical sciences, including developments in analytical methodology, instrumentation, computation and interpretation. Submissions on novel applications focusing on drug purity and stability studies, pharmacokinetics, therapeutic monitoring, metabolic profiling; drug-related aspects of analytical biochemistry and forensic toxicology; quality assurance in the pharmaceutical industry are also welcome. Studies from areas of well established and poorly selective methods, such as UV-VIS spectrophotometry (including derivative and multi-wavelength measurements), basic electroanalytical (potentiometric, polarographic and voltammetric) methods, fluorimetry, flow-injection analysis, etc. are accepted for publication in exceptional cases only, if a unique and substantial advantage over presently known systems is demonstrated. The same applies to the assay of simple drug formulations by any kind of methods and the determination of drugs in biological samples based merely on spiked samples. Drug purity/stability studies should contain information on the structure elucidation of the impurities/degradants.