A Biochemical Investigation of the Prevalence of Hypercalcemia and Thiazide-Related Hypercalcemia in Patients.

IF 1.1 Q4 PHARMACOLOGY & PHARMACY
Shariq Rashid Masoodi, Moomin Hussain Bhat, Imtiyaz Ahmed Najar, Mosin S Khan, Javaid Rasool Bhat, Sazal Patyar, Poonam Arora, Manish Kumar
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Abstract

Objective: Hypercalcemia allied with thiazide diuretics is a widely acknowledged clinical presentation. Hence, the purpose of this investigation was to ascertain the prevalence of hypercalcemia and hypercalcemia linked to thiazides and to evaluate serum phosphorous, 25- hydroxyvitamin D, and parathyroid hormone (PTH).

Methods: This prospective, cross-sectional research study involved all patients, including outpatients, and was conducted over a 12-month period. Between December 2017 and December 2018, an aggregate of 373 patients were enrolled. All patients with hypercalcemia (albumincorrected serum calcium > 10.8 mg/dL) had their medical information put on a proforma, together with the results of any tests (such as parathyroid hormone (PTH), 25-hydroxyvitamin D, and serum phosphorus).

Results: Out of 373 subjects, 7 (2%) were hypercalcemic. The mean corrected calcium levels in the normo-calcemic group were 9.46 ± 0.60 mg/dL (95% CI, 9.4 - 9.5), and that in the hypercalcemic group were 11.68 ± 0.82 mg/dL (95% CI, 10.9 - 12.4). Of the seven cases of hypercalcemia, 2 patients (28.6%) had thiazide-associated hypercalcemia (TAH) along with primary hyperparathyroidism (PHPT). Of the remaining 5 hypercalcemia patients, two more had PHPT, and one (14.3%) had hypervitaminosis D, whereas no cause was mentioned in the remaining 2 patients. Among the 4 PHPT patients, corrected calcium was slightly higher in those with TAH vs those without TAH, though the difference was statistically insignificant (11.32 ± 0.43 vs 11.14 ± 0.39 mg/dL; P > 0.7).

Conclusion: TAH is the second primary cause of asymptomatic hypercalcemia after PHPT. Thus, close coordination between the clinicians, pharmacology, pharmacovigilance, and the biochemistry department may help in identifying these cases.

患者高钙血症及噻嗪类药物相关性高钙血症的生化调查。
目的:高钙血症联合噻嗪类利尿剂是一种广泛认可的临床表现。因此,本研究的目的是确定高钙血症和与噻嗪类药物相关的高钙血症的患病率,并评估血清磷、25-羟基维生素D和甲状旁腺激素(PTH)。方法:这项前瞻性横断面研究涉及所有患者,包括门诊患者,并进行了为期12个月的研究。在2017年12月至2018年12月期间,共有373名患者入组。所有高钙血症患者(白蛋白校正的血清钙> 10.8 mg/dL)的医疗信息都被填写在表格上,并附有任何测试结果(如甲状旁腺激素(PTH)、25-羟基维生素D和血清磷)。结果:在373例受试者中,7例(2%)为高钙血症。正常钙血症组校正后的平均钙水平为9.46±0.60 mg/dL (95% CI, 9.4 - 9.5),高钙血症组校正后的平均钙水平为11.68±0.82 mg/dL (95% CI, 10.9 - 12.4)。在7例高钙血症患者中,2例(28.6%)合并噻嗪类药物相关性高钙血症(TAH)和原发性甲状旁腺功能亢进(PHPT)。在剩下的5例高钙血症患者中,又有2例患有PHPT, 1例(14.3%)患有维生素D过多症,而在剩下的2例患者中没有提到病因。在4例PHPT患者中,有TAH患者的校正钙略高于无TAH患者,但差异无统计学意义(11.32±0.43 vs 11.14±0.39 mg/dL;P > 0.7)。结论:TAH是继PHPT之后无症状性高钙血症的第二大病因。因此,临床医生、药理学、药物警戒和生物化学部门之间的密切协调可能有助于识别这些病例。
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来源期刊
Current drug safety
Current drug safety PHARMACOLOGY & PHARMACY-
CiteScore
2.10
自引率
0.00%
发文量
112
期刊介绍: Current Drug Safety publishes frontier articles on all the latest advances on drug safety. The journal aims to publish the highest quality research articles, reviews and case reports in the field. Topics covered include: adverse effects of individual drugs and drug classes, management of adverse effects, pharmacovigilance and pharmacoepidemiology of new and existing drugs, post-marketing surveillance. The journal is essential reading for all researchers and clinicians involved in drug safety.
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