Melittin, A Potential Game-changer in the Fight Against Breast Cancer: A Systematic Review.

IF 2.6 4区医学 Q3 CHEMISTRY, MEDICINAL

Anti-cancer agents in medicinal chemistry Pub Date : 2025-02-25 DOI:10.2174/0118715206347581250217045306

Gilles Prince, Ahmad Assi, Marc Aoude, Hampig Raphael Kourie, Fadi Haddad

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引用次数: 0

Abstract

Introduction: Breast cancer is the most common cancer in women. Traditional treatments include endocrine therapy, chemotherapy, surgery, radiation, and immunotherapy. Recent studies suggest melittin, a component of bee venom, as a promising breast cancer treatment due to its anticancer properties: inducing cytotoxicity, apoptosis, and gene regulation.

Method: This manuscript aims to review melittin's potential therapeutical and future implications in treating breast cancer. An extensive literature search was conducted on MEDLINE and Cochrane databases up to July 2024 using Boolean operators with a combination of keywords. After screening, data extraction, and descriptive analysis, 40 articles were retained.

Results: Experimental data and different therapeutical strategies were collected. Melittin disrupts tumor cell membranes and modulates key apoptotic pathways. Advanced delivery systems enhance their effectiveness and reduce toxicity. Combining melittin with chemotherapy shows synergistic effects, improving outcomes. Thus, melittin could be a valuable addition to breast cancer therapies.

Conclusion: Further clinical trials are essential to validate its potential and establish its role in breast cancer therapy.

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Melittin，对抗乳腺癌的潜在游戏规则改变者：一项系统综述。

乳腺癌是女性中最常见的癌症。传统的治疗方法包括内分泌治疗、化疗、手术、放疗和免疫治疗。最近的研究表明蜂毒是蜂毒的一种成分，由于其抗癌特性：诱导细胞毒性、细胞凋亡和基因调控，蜂毒素是一种很有前途的乳腺癌治疗药物。方法：本文旨在回顾蜂毒素治疗乳腺癌的潜在治疗和未来意义。在MEDLINE和Cochrane数据库上进行了广泛的文献检索，检索截止到2024年7月，使用布尔运算符和关键词组合。经筛选、资料提取、描述性分析，保留40篇文章。结果：收集了实验数据和不同的治疗策略。蜂毒素破坏肿瘤细胞膜并调节关键的凋亡途径。先进的输送系统提高了它们的有效性并降低了毒性。蜂毒素联合化疗具有协同作用，改善了预后。因此，蜂毒素可能是乳腺癌治疗的一个有价值的补充。结论：需要进一步的临床试验来验证其在乳腺癌治疗中的潜力和作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anti-cancer agents in medicinal chemistry ONCOLOGY-CHEMISTRY, MEDICINAL

CiteScore

5.10

自引率

3.60%

发文量

323

审稿时长

4-8 weeks

期刊介绍： Formerly: Current Medicinal Chemistry - Anti-Cancer Agents. Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents. Each issue contains a series of timely in-depth reviews and guest edited issues written by leaders in the field covering a range of current topics in cancer medicinal chemistry. The journal only considers high quality research papers for publication. Anti-Cancer Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cancer drug discovery.