Amphiphilic Acyclic Cucurbit[n]uril: Synthesis, Self-Assembly, and Chemotherapeutic Delivery to Overcome Multidrug Resistance.

IF 4.5 2区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Molecular Pharmaceutics Pub Date : 2025-02-26 DOI:10.1021/acs.molpharmaceut.5c00012

Zizhen Zhao, Danying Ma, Shuyi Wang, Wei Zhou, Dan-Wei Zhang, Zhan-Ting Li, Da Ma

引用次数: 0

Abstract

A new amphiphilic acyclic cucurbit[n]uril (CB[n]) is designed and synthesized. This amphiphilic acyclic CB[n] could encapsulate pharmaceutical drugs via a host-guest interaction. Self-assembly of this acyclic CB[n] forms spherical nanoparticles with diameters of 91 nm in water. The self-assembled nanoparticles are capable of delivering doxorubicin with high efficiency. Cell experiments show that the doxorubicin-loaded nanoparticles can improve cellular uptake and cytotoxicity by using the MCF-7/ADR cell line. The A549 tumor-bearing mouse model shows that self-assembled nanoparticles help overcome multidrug resistance in vivo. Cell study and histological assays confirm the biocompatibility of self-assembled nanoparticles.

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来源期刊

Molecular Pharmaceutics 医学-药学

CiteScore

8.00

自引率

6.10%

发文量

391

审稿时长

2 months

期刊介绍： Molecular Pharmaceutics publishes the results of original research that contributes significantly to the molecular mechanistic understanding of drug delivery and drug delivery systems. The journal encourages contributions describing research at the interface of drug discovery and drug development. Scientific areas within the scope of the journal include physical and pharmaceutical chemistry, biochemistry and biophysics, molecular and cellular biology, and polymer and materials science as they relate to drug and drug delivery system efficacy. Mechanistic Drug Delivery and Drug Targeting research on modulating activity and efficacy of a drug or drug product is within the scope of Molecular Pharmaceutics. Theoretical and experimental peer-reviewed research articles, communications, reviews, and perspectives are welcomed.