Rh-Catalyzed and Self-Directed Aromatic C-H Activation of Enaminones to Divergent Alkenylated and Annulated Compounds.

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-02-27 DOI:10.1021/acs.orglett.5c00213

Demao Chen, Jie-Ping Wan, Yunyun Liu

引用次数: 0

Abstract

By means of simple Rh catalysis, the direct activation of the ortho-C-H bond in aryl enaminones has been realized with the enaminone structure as a traceless directing fragment. The products resulting from C-H alkenylation and further annulation via intramolecular C-H bond addition could be accessed depending upon the structure of alkenes. The annulated products could be used for the easy synthesis of valuable 2-aza-fluorenones in a one-pot operation by employing NH₄OAc.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.