What outcomes are important to people with foot and ankle disorders in rheumatic and musculoskeletal diseases? An OMERACT qualitative interview study across four continents

IF 4.6 2区医学 Q1 RHEUMATOLOGY

Seminars in arthritis and rheumatism Pub Date : 2025-02-22 DOI:10.1016/j.semarthrit.2025.152671

Lara S. Chapman , Caroline A. Flurey , Pamela Richards , Anthony C. Redmond , Eiman Soliman , Abdelhfeez Moshrif , Lucy Malone , Christopher Joyce , John B. Arnold , Yvonne M. Golightly , Catherine Hofstetter , Philip S. Helliwell , Hylton B. Menz , Marian T. Hannan , Md Nazibur Rahman , Beverley J. Shea , Toby O. Smith , Heidi J. Siddle

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引用次数: 0

Abstract

Background

The foot and ankle are frequently affected in rheumatic and musculoskeletal diseases (RMDs), yet there is a lack of high-quality evidence to determine the effectiveness of treatments. Outcomes in research are often inconsistently measured, impeding evidence synthesis. Additionally, clinical decisions are based on research outcomes, but these are not always regarded as important by people with RMDs. This study aimed to determine domains of importance to people with RMDs who have experienced foot and ankle disorders, and aid in developing a standardised core outcome set (COS) to address these issues.

Methods

Participants from four continents (Europe, Africa, Australia, North America) were recruited to semi-structured interviews through clinical departments and electronic mailing lists. Analysis was conducted using a mixed deductive/inductive approach to the framework method. Patient research partners co-produced the interview schedule and recruitment materials, and co-interpreted results.

Results

Fifty-six participants (age range 27 to 76 years; 66 % female), with foot and ankle disorders in a variety of RMDs (including inflammatory arthritis, osteoarthritis, crystal arthropathies, connective tissue diseases), were interviewed. Sixteen domains were described by participants: pain, physical function, fatigue, deformity, skin and nail health, swelling, temperature, numbness, poor circulation, cramping, activities/participation, footwear impact, psychological impact, sleep, healthcare utilisation and personal expenses. Most domains were considered important to participants regardless of RMD or geographic location.

Conclusions

Foot and ankle disorders have far-reaching consequences for people with RMDs. This large qualitative study provides a foundation for achieving international consensus on a core outcome set for foot and ankle disorders in RMDs, to improve the quality of evidence demonstrating effectiveness of treatments.

查看原文本刊更多论文

对于患有风湿性和肌肉骨骼疾病的足部和踝关节疾病的人来说，哪些结果是重要的？一项横跨四大洲的OMERACT定性访谈研究

在风湿病和肌肉骨骼疾病（RMDs）中，足部和踝关节经常受到影响，但缺乏高质量的证据来确定治疗的有效性。研究结果的测量常常不一致，妨碍了证据的合成。此外，临床决策是基于研究结果，但这些并不总是被rmd患者视为重要的。本研究旨在确定患有足部和踝关节疾病的rmd患者的重要领域，并帮助制定标准化的核心结果集（COS）来解决这些问题。方法从四大洲（欧洲、非洲、澳大利亚、北美）通过临床科室和电子邮件列表招募参与者进行半结构化访谈。采用混合演绎/归纳方法对框架方法进行分析。患者研究伙伴共同制定面试时间表和招聘材料，并共同解释结果。结果56例受试者，年龄27 ~ 76岁；（66%为女性），在各种rmd（包括炎症性关节炎、骨关节炎、晶体关节病、结缔组织疾病）中患有足部和踝关节疾病。参与者描述了16个领域：疼痛、身体功能、疲劳、畸形、皮肤和指甲健康、肿胀、温度、麻木、血液循环不良、抽筋、活动/参与、鞋类影响、心理影响、睡眠、医疗保健利用和个人支出。无论RMD或地理位置如何，大多数领域都被认为对参与者很重要。结论足部和踝关节疾病对rmd患者具有深远的影响。这项大型定性研究为在rmd足部和踝关节疾病的核心结果上达成国际共识奠定了基础，以提高证明治疗有效性的证据质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in arthritis and rheumatism 医学-风湿病学

CiteScore

9.20

自引率

4.00%

发文量

176

审稿时长

46 days

期刊介绍： Seminars in Arthritis and Rheumatism provides access to the highest-quality clinical, therapeutic and translational research about arthritis, rheumatology and musculoskeletal disorders that affect the joints and connective tissue. Each bimonthly issue includes articles giving you the latest diagnostic criteria, consensus statements, systematic reviews and meta-analyses as well as clinical and translational research studies. Read this journal for the latest groundbreaking research and to gain insights from scientists and clinicians on the management and treatment of musculoskeletal and autoimmune rheumatologic diseases. The journal is of interest to rheumatologists, orthopedic surgeons, internal medicine physicians, immunologists and specialists in bone and mineral metabolism.