Exploring the potential of stem cell therapy: Applications, types, and future directions

IF 2.4 4区生物学 Q4 CELL BIOLOGY

Acta histochemica Pub Date : 2025-02-27 DOI:10.1016/j.acthis.2025.152237

KeerthiShri Boopathy , Thirunavukkarasu Palaniyandi , Maddaly Ravi , Mugip Rahaman Abdul Wahab , Gomathy Baskar , Safia Obaidur Rab , Mohd Saeed , Vishal M. Balaramnavar

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Abstract

One of the most significant treatment approaches now accessible is stem cell therapy. Over the last few decades, a lot of study has been done in this field, and this fascinating feature of plasticity could have therapeutic uses. The potential of stem cells to restore function lost as a result of disease, trauma, congenital defects, and age has made stem cell research a key priority for scientific and medical organizations across the world. Stem cells are a crucial topic of study in regenerative medicine because of their capacity to replace, repair, or regenerate damaged cells, tissues, or organs. As a result, stem cell therapy is being used as a treatment strategy for a number of illnesses. Because stem cells may proliferate indefinitely and generate vast quantities of differentiated cells needed for transplantation, they hold enormous promise for regenerative medicine. Stem cells can be reprogrammed from adult cell types or originate from embryonic or fetal origins. Depending on their availability and place of origin, stem cells can be totipotent, pluripotent, multipotent, oligopotent, or unipotent. With stem cell treatment, many ailments, including diabetes, liver disease, infertility, wounds and traumas, neurological disorders, cardiovascular disease, and cancer, might be cured. Various types of stem cell treatment are described in this review along with their applications in different therapeutic fields, ethical considerations, and advantages and disadvantages.

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探索干细胞治疗的潜力：应用、类型和未来方向

目前最重要的治疗方法之一是干细胞治疗。在过去的几十年里，在这个领域进行了大量的研究，可塑性这个迷人的特征可以用于治疗。干细胞具有恢复因疾病、创伤、先天性缺陷和年龄而丧失的功能的潜力，这使得干细胞研究成为世界各地科学和医疗组织的一个关键优先事项。干细胞具有替代、修复或再生受损细胞、组织或器官的能力，是再生医学研究的一个重要课题。因此，干细胞疗法正被用作许多疾病的治疗策略。由于干细胞可以无限增殖并产生移植所需的大量分化细胞，因此它们在再生医学方面具有巨大的前景。干细胞可以从成体细胞类型中重新编程，也可以来自胚胎或胎儿起源。根据干细胞的可获得性和来源，干细胞可以是全能性、多能性、多能性、寡能性或单能性。通过干细胞治疗，许多疾病，包括糖尿病、肝病、不孕症、伤口和创伤、神经系统疾病、心血管疾病和癌症，都可能被治愈。本文介绍了各种类型的干细胞治疗，以及它们在不同治疗领域的应用、伦理考虑和优缺点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta histochemica 生物-细胞生物学

CiteScore

4.60

自引率

4.00%

发文量

107

审稿时长

23 days

期刊介绍： Acta histochemica, a journal of structural biochemistry of cells and tissues, publishes original research articles, short communications, reviews, letters to the editor, meeting reports and abstracts of meetings. The aim of the journal is to provide a forum for the cytochemical and histochemical research community in the life sciences, including cell biology, biotechnology, neurobiology, immunobiology, pathology, pharmacology, botany, zoology and environmental and toxicological research. The journal focuses on new developments in cytochemistry and histochemistry and their applications. Manuscripts reporting on studies of living cells and tissues are particularly welcome. Understanding the complexity of cells and tissues, i.e. their biocomplexity and biodiversity, is a major goal of the journal and reports on this topic are especially encouraged. Original research articles, short communications and reviews that report on new developments in cytochemistry and histochemistry are welcomed, especially when molecular biology is combined with the use of advanced microscopical techniques including image analysis and cytometry. Letters to the editor should comment or interpret previously published articles in the journal to trigger scientific discussions. Meeting reports are considered to be very important publications in the journal because they are excellent opportunities to present state-of-the-art overviews of fields in research where the developments are fast and hard to follow. Authors of meeting reports should consult the editors before writing a report. The editorial policy of the editors and the editorial board is rapid publication. Once a manuscript is received by one of the editors, an editorial decision about acceptance, revision or rejection will be taken within a month. It is the aim of the publishers to have a manuscript published within three months after the manuscript has been accepted