{"title":"Glomerulonephritis with Positive Anti-Glomerular Basement Membrane Antibodies following COVID-19 Vaccine.","authors":"Y Fahy, E White, D Lappin","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Presentation: </strong>A 78 year old female presented to the emergency department with a one day history of haemoptysis, cough, fever and shortness of breath. This was two days after the second dose of her Covid-19 mRNA vaccine.</p><p><strong>Diagnosis: </strong>A diagnosis of vaccine-mediated anti-glomerular basement membrane antibody (anti-GBM) disease (or Goodpasture's Syndrome) was made after a vasculitic screen was sent for suspected glomerulonephritis.</p><p><strong>Treatment: </strong>She was treated with IV Methylprednisolone 1000mg IV for three days, seven sequential sessions of plasmapheresis and pulsed IV Cyclophosphamide, with resolution of haemoptysis and kidney function.</p><p><strong>Discussion: </strong>It is important to maintain a high index of suspicion and test for anti-GBM disease in patients receiving SARS-CoV-2 mRNA vaccination.</p>","PeriodicalId":14713,"journal":{"name":"Irish medical journal","volume":"118 2","pages":"27"},"PeriodicalIF":0.0000,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Irish medical journal","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Presentation: A 78 year old female presented to the emergency department with a one day history of haemoptysis, cough, fever and shortness of breath. This was two days after the second dose of her Covid-19 mRNA vaccine.
Diagnosis: A diagnosis of vaccine-mediated anti-glomerular basement membrane antibody (anti-GBM) disease (or Goodpasture's Syndrome) was made after a vasculitic screen was sent for suspected glomerulonephritis.
Treatment: She was treated with IV Methylprednisolone 1000mg IV for three days, seven sequential sessions of plasmapheresis and pulsed IV Cyclophosphamide, with resolution of haemoptysis and kidney function.
Discussion: It is important to maintain a high index of suspicion and test for anti-GBM disease in patients receiving SARS-CoV-2 mRNA vaccination.
期刊介绍：
Since its inception in 1867, the Journal of the Medical Association of Ireland and now in its present format, the Irish Medical Journal, has provided the medical community in Ireland with an invaluable service. As one of the leading biomedical publications in Ireland, it has sought to continue the education of medical students and postgraduates through scientific research, review articles and updates on contemporary clinical practices while providing an ongoing forum for medical debate. A measure of our stature is that we are listed in the Index Medicus and issued annually with a citation factor from the Institute for Scientific Information.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
