Glioblastoma multiforme: insights into pathogenesis, key signaling pathways, and therapeutic strategies

IF 27.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cancer Pub Date : 2025-02-26 DOI:10.1186/s12943-025-02267-0

Ashkan Pouyan, Masoud Ghorbanlo, Masoud Eslami, Majid Jahanshahi, Ehsan Ziaei, Ali Salami, Khatere Mokhtari, Koorosh Shahpasand, Najma Farahani, Tohid Emami Meybodi, Maliheh Entezari, Afshin Taheriazam, Kiavash Hushmandi, Mehrdad Hashemi

引用次数: 0

Abstract

Glioblastoma multiforme (GBM) is the most prevalent and aggressive primary brain tumor in adults, characterized by a poor prognosis and significant resistance to existing treatments. Despite progress in therapeutic strategies, the median overall survival remains approximately 15 months. A hallmark of GBM is its intricate molecular profile, driven by disruptions in multiple signaling pathways, including PI3K/AKT/mTOR, Wnt, NF-κB, and TGF-β, critical to tumor growth, invasion, and treatment resistance. This review examines the epidemiology, molecular mechanisms, and therapeutic prospects of targeting these pathways in GBM, highlighting recent insights into pathway interactions and discovering new therapeutic targets to improve patient outcomes.

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多形性胶质母细胞瘤：对发病机制、关键信号通路和治疗策略的见解

多形性胶质母细胞瘤（GBM）是成人中最常见和侵袭性最强的原发性脑肿瘤，其特点是预后差，对现有治疗有明显的耐药性。尽管治疗策略取得了进展，但中位总生存期仍约为15个月。GBM的一个特点是其复杂的分子特征，由多种信号通路的中断驱动，包括PI3K/AKT/mTOR、Wnt、NF-κB和TGF-β，这些信号通路对肿瘤生长、侵袭和治疗耐药性至关重要。本文综述了GBM的流行病学、分子机制和靶向这些通路的治疗前景，重点介绍了通路相互作用的最新见解，并发现了新的治疗靶点，以改善患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Cancer 医学-生化与分子生物学

CiteScore

54.90

自引率

2.70%

发文量

224

审稿时长

2 months

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