A pharmacovigilance study based on the FAERS database focusing on anticoagulant and hormonal drugs that induce vaginal hemorrhage.

IF 1.9 Q3 PHARMACOLOGY & PHARMACY
Drug Discoveries and Therapeutics Pub Date : 2025-03-06 Epub Date: 2025-02-23 DOI:10.5582/ddt.2024.01071
Ruohan Li, Panwei Hu, Lin Qian
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引用次数: 0

Abstract

Numerous medications have been associated with an increased risk of vaginal hemorrhage in women. In this study, we analyzed data from the FDA Adverse Event Reporting System (FAERS), focusing on reports of drug-induced vaginal bleeding in women. Risk signals were assessed using disproportionality analyses, specifically the reporting odds ratio (ROR) and the proportional reporting ratio (PRR), to identify significant associations between drugs and adverse events. We found that anticoagulants, hormonal drugs, psychotropic drugs, hypoglycemic agents, antineoplastic agents, anti-inflammatory drugs, immunological agents, and some drugs for osteoporosis were significantly associated with the risk of vaginal hemorrhage. Hormonal drugs, anticoagulants, and particularly antifungal agents were attributed to a notably high proportion of vaginal hemorrhage cases, necessitating further investigation into the underlying mechanisms. Therefore, precise clinical management of medications and optimization of treatment regimens are necessary to reduce the risk of vaginal hemorrhage and improve safety.

一项基于FAERS数据库的药物警戒研究,重点关注引起阴道出血的抗凝血药物和激素药物。
许多药物与女性阴道出血的风险增加有关。在这项研究中,我们分析了来自FDA不良事件报告系统(FAERS)的数据,重点关注女性药物性阴道出血的报告。使用歧化分析评估风险信号,特别是报告优势比(ROR)和比例报告比(PRR),以确定药物与不良事件之间的显著关联。我们发现抗凝剂、激素类药物、精神类药物、降糖药、抗肿瘤药物、抗炎药物、免疫药物和一些骨质疏松药物与阴道出血的风险显著相关。激素药物,抗凝剂,特别是抗真菌药物被认为是阴道出血病例的高比例,需要进一步研究其潜在机制。因此,精确的临床用药管理和优化治疗方案是降低阴道出血风险和提高安全性的必要条件。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Drug Discoveries and Therapeutics
Drug Discoveries and Therapeutics PHARMACOLOGY & PHARMACY-
CiteScore
3.20
自引率
3.20%
发文量
51
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