Emerging role of mesenchymal cells in cardiac and cerebrovascular diseases: Physiology, pathology, and therapeutic implications

IF 3.5 3区医学 Q2 PHARMACOLOGY & PHARMACY

Vascular pharmacology Pub Date : 2025-02-22 DOI:10.1016/j.vph.2025.107473

Kajal Kumari , Kanika Verma , Meenal Sahu , Jaya Dwivedi , Sarvesh Paliwal , Swapnil Sharma

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引用次数: 0

Abstract

In recent years, the therapeutic utility of mesenchymal stem cells (MSCs) has received substantial attention from investigators, owing to their pleiotropic properties. The emerging insights from the developments in tissue engineering provide perspectives for the repair of damaged tissue and the replacement of failing organs. Perivascular cells including MSC-like pericytes, vascular smooth muscles, and other cells located around blood vessels, have been acknowledged to contribute to in situ angiogenesis and repair process. MSCs offer a wide array of therapeutic applications in different pathological states. However, in the current article, we have highlighted the recent updates on MSCs and their key applications in cardiac and cerebrovascular diseases, evident in different preclinical and clinical studies. We believe the present article would assist the investigators in understanding the recent advances of MSCs and exploring their therapeutic potential in varied ailments, especially cardiac and cerebrovascular diseases.

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间充质细胞在心脑血管疾病中的新作用：生理、病理和治疗意义。

近年来，由于间充质干细胞（MSCs）具有多种特性，其治疗作用受到了研究人员的极大关注。组织工程学的发展为修复受损组织和替代衰竭器官提供了新的视角。血管周围细胞，包括间充质干细胞样周细胞、血管平滑肌和其他位于血管周围的细胞，被认为有助于原位血管生成和修复过程。间充质干细胞可在不同病理状态下提供广泛的治疗应用。然而，在本文中，我们重点介绍了间充质干细胞的最新进展及其在心脑血管疾病中的主要应用，这些在不同的临床前和临床研究中均有体现。我们相信，本文将有助于研究人员了解间充质干细胞的最新进展，并探索其在各种疾病（尤其是心脑血管疾病）中的治疗潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Vascular pharmacology 医学-药学

CiteScore

6.60

自引率

2.50%

发文量

153

审稿时长

31 days

期刊介绍： Vascular Pharmacology publishes papers, which contains results of all aspects of biology and pharmacology of the vascular system. Papers are encouraged in basic, translational and clinical aspects of Vascular Biology and Pharmacology, utilizing approaches ranging from molecular biology to integrative physiology. All papers are in English. The Journal publishes review articles which include vascular aspects of thrombosis, inflammation, cell signalling, atherosclerosis, and lipid metabolism.