{"title":"Optimizing antibiotic use in MSSA bacteremia: a stewardship-focused approach.","authors":"Victoria L Campodónico","doi":"10.1128/spectrum.03163-24","DOIUrl":null,"url":null,"abstract":"<p><p>Antimicrobial stewardship is essential for optimizing therapy in bloodstream infections. Methicillin-susceptible <i>Staphylococcus aureus</i> (MSSA) bacteremia requires prompt beta-lactam treatment, and delays in transitioning from empirical anti-MRSA therapy can result in adverse outcomes. Rapid diagnostics like the BioFire Blood Culture Identification (BCID) PCR panel, combined with stewardship interventions, significantly improve care by reducing unnecessary broad-spectrum antimicrobial use. A study by Yetukuri et al. demonstrated that integrating BCID with stewardship efforts reduced time to optimal therapy by 20 h (49 vs 29.1 h, <i>P</i> < 0.001) and shortened both bacteremia duration and anti-MRSA therapy without affecting mortality or hospital stay. These findings emphasize that stewardship programs, including real-time reviews and prescriptive guidance, are critical for translating rapid diagnostic results into timely, targeted treatment. Leveraging stewardship with advanced diagnostics offers a strategic approach to enhancing outcomes and combating antimicrobial resistance.</p>","PeriodicalId":18670,"journal":{"name":"Microbiology spectrum","volume":" ","pages":"e0316324"},"PeriodicalIF":3.7000,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microbiology spectrum","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1128/spectrum.03163-24","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Antimicrobial stewardship is essential for optimizing therapy in bloodstream infections. Methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia requires prompt beta-lactam treatment, and delays in transitioning from empirical anti-MRSA therapy can result in adverse outcomes. Rapid diagnostics like the BioFire Blood Culture Identification (BCID) PCR panel, combined with stewardship interventions, significantly improve care by reducing unnecessary broad-spectrum antimicrobial use. A study by Yetukuri et al. demonstrated that integrating BCID with stewardship efforts reduced time to optimal therapy by 20 h (49 vs 29.1 h, P < 0.001) and shortened both bacteremia duration and anti-MRSA therapy without affecting mortality or hospital stay. These findings emphasize that stewardship programs, including real-time reviews and prescriptive guidance, are critical for translating rapid diagnostic results into timely, targeted treatment. Leveraging stewardship with advanced diagnostics offers a strategic approach to enhancing outcomes and combating antimicrobial resistance.
期刊介绍：
Microbiology Spectrum publishes commissioned review articles on topics in microbiology representing ten content areas: Archaea; Food Microbiology; Bacterial Genetics, Cell Biology, and Physiology; Clinical Microbiology; Environmental Microbiology and Ecology; Eukaryotic Microbes; Genomics, Computational, and Synthetic Microbiology; Immunology; Pathogenesis; and Virology. Reviews are interrelated, with each review linking to other related content. A large board of Microbiology Spectrum editors aids in the development of topics for potential reviews and in the identification of an editor, or editors, who shepherd each collection.
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