The Role of Ferritin and Folate in Determining Stem Cell Collection for Autologous Stem Cell Transplant in Multiple Myeloma.

IF 1.1 Q4 HEMATOLOGY

Hematology Reports Pub Date : 2025-01-24 DOI:10.3390/hematolrep17010005

Charles J Weeks, Mohammad Mian, Michael Stokes, Matthew Gold, Anvay Shah, Rohan Vuppala, Katherine J Kim, Abigayle B Simon, Jorge Cortes, Anand Jillela, Vamsi Kota

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Abstract

Background: An autologous stem cell transplant (ASCT) is the standard of care for eligible patients with multiple myeloma (MM). However, the success of ASCT largely hinges on efficient mobilization; thus, a thorough analysis of factors that may affect mobilization is essential.

Methods: The study consists of a single-center, retrospective chart review of 292 adult patients undergoing their first or second autologous transplantation for MM from 2016 to 2023. Patient demographics, serum lab values at the pre-collection evaluation visit, total stem cell capture (TC) in CD34/kg × 10⁶ stem cell capture on the first day of apheresis (FC) in CD34/kg × 10⁶, and the total number of days of apheresis (DOA) were retrieved from the electronic medical record (EMR).

Results: Individuals with high folate levels experienced less DOA (1.43 ± 0.61) compared to those with normal folate levels (1.68 ± 0.82, p = 0.013). The high-folate group had a greater FC (3.26 ± 1.07) compared to the normal-folate group (2.88 ± 1.13, p = 0.013). High ferritin levels were associated with more DOA (1.79 ± 0.89) compared to the normal-ferritin group (1.51 ± 0.67, p = 0.034). Moderate anemia was significantly associated with decreased FC (p = 0.023) and increased DOA (p = 0.030). Abnormal hemoglobin (Hgb), ferritin, and folate statuses did not exhibit significant differences in survival analysis.

Conclusions: The findings reveal that folate, ferritin, and Hgb levels are significantly associated with apheresis outcomes, offering guidance for optimizing stem cell mobilization in patients with MM.

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铁蛋白和叶酸在多发性骨髓瘤自体干细胞移植干细胞收集中的作用。

背景：自体干细胞移植（ASCT）是符合条件的多发性骨髓瘤（MM）患者的标准治疗。然而，ASCT的成功在很大程度上取决于有效的动员；因此，对可能影响动员的因素进行彻底分析是必不可少的。方法：本研究采用单中心、回顾性图表回顾的方法，对2016年至2023年接受首次或第二次自体骨髓移植的292例成年MM患者进行研究。从电子病历（EMR）中检索患者的人口统计资料、采集前评估访问时的血清实验室值、采血第一天的干细胞捕获总量（TC）（CD34/kg × 106）和采血总天数（DOA）。结果：叶酸水平高的人的DOA（1.43±0.61）低于叶酸水平正常的人（1.68±0.82,p = 0.013）。高叶酸组的FC（3.26±1.07）高于正常叶酸组（2.88±1.13,p = 0.013）。与铁蛋白正常组（1.51±0.67,p = 0.034）相比，高铁蛋白水平组的DOA（1.79±0.89）更高。中度贫血与FC降低（p = 0.023）和DOA升高（p = 0.030）显著相关。异常血红蛋白（Hgb）、铁蛋白和叶酸状态在生存分析中没有显着差异。结论：研究结果显示叶酸、铁蛋白和血红蛋白水平与分离结果显著相关，为优化MM患者的干细胞动员提供了指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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