The Cost Effectiveness of Adjunctive Medical Cannabis Therapy in the Treatment of Moderate Post-Traumatic Stress Disorder.

IF 2.9 3区 医学 Q2 PHARMACOLOGY & PHARMACY
Clinical Drug Investigation Pub Date : 2025-04-01 Epub Date: 2025-02-25 DOI:10.1007/s40261-025-01424-z
Mitchell L Doucette, Dipak Hemraj, D Luke Macfarlan, Junella Chin, Emily Fisher
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Abstract

Introduction: Research on the benefits of medical cannabis (MC) is emerging and supports its use as a treatment for post-traumatic stress disorder (PTSD). This study aimed to evaluate the cost effectiveness of MC as an adjunctive therapy for moderate PTSD under varying reimbursement scenarios.

Methods: A cost-utility analysis was conducted from the US payor perspective, using pricing data from the largest multi-state MC producer and established literature on standard PTSD treatments. We analyzed eight MC product types: dried flower, oral solutions, tablets, and edibles, each available in low/moderate (LM) and high-cost formulations. Incremental cost-utility ratios (ICURs) were calculated for these products across reimbursement levels of 100%, 75%, 50%, and 25%. Probabilistic sensitivity analyses with 10,000 Monte Carlo simulations were conducted to assess cost-effectiveness acceptability across willingness-to-pay (WTP) thresholds of $0-$100,000 per quality-adjusted life year (QALY) gained.

Results: Non-flower MC products (edibles, oral solutions, and tablets) consistently demonstrated cost-effectiveness under a WTP threshold of $50,000, even at 100% reimbursement. Dried flower products, while less cost effective due to higher costs, achieved cost effectiveness under 75% or lower reimbursement levels for LM cost formulations. Sensitivity analyses confirmed robust ICURs for non-flower products, with narrower variability compared to dried flower products.

Conclusions: Medical cannabis products, particularly non-flower formulations, represent a cost-effective adjunctive therapy for moderate PTSD under various reimbursement scenarios. This analysis underscores the importance of evidence-based reimbursement policies to improve patient access to cost-effective treatments while ensuring financial sustainability for payors.

辅助医用大麻治疗中度创伤后应激障碍的成本效益。
导言:关于医用大麻(MC)益处的研究正在兴起,并支持将其用作创伤后应激障碍(PTSD)的治疗。本研究旨在评估在不同报销方案下,MC作为一种辅助治疗中度创伤后应激障碍的成本效益。方法:从美国付款人的角度进行成本效用分析,使用最大的多州MC生产商的定价数据和关于标准PTSD治疗的既定文献。我们分析了8种MC产品类型:干花、口服液、片剂和可食剂,每种产品都有低/中等(LM)和高成本配方。在100%、75%、50%和25%的报销水平下,计算这些产品的增量成本效用比(ICURs)。通过1万次蒙特卡罗模拟进行概率敏感性分析,评估每个获得的质量调整生命年(QALY)的支付意愿(WTP)阈值为0- 10万美元时的成本效益可接受性。结果:即使在100%报销的情况下,在WTP阈值为50,000美元的情况下,非花MC产品(食用,口服溶液和片剂)始终显示出成本效益。由于成本较高,干花产品的成本效益较低,但其成本效益低于75%或低于LM成本配方的报销水平。敏感性分析证实了非花产品的稳健ICURs,与干花产品相比变异性更窄。结论:在各种报销方案下,医用大麻产品,特别是非花制剂,代表了一种具有成本效益的中等创伤后应激障碍辅助治疗。这一分析强调了以证据为基础的报销政策的重要性,以改善患者获得具有成本效益的治疗,同时确保付款人的财务可持续性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.90
自引率
3.10%
发文量
108
审稿时长
6-12 weeks
期刊介绍: Clinical Drug Investigation provides rapid publication of original research covering all phases of clinical drug development and therapeutic use of drugs. The Journal includes: -Clinical trials, outcomes research, clinical pharmacoeconomic studies and pharmacoepidemiology studies with a strong link to optimum prescribing practice for a drug or group of drugs. -Clinical pharmacodynamic and clinical pharmacokinetic studies with a strong link to clinical practice. -Pharmacodynamic and pharmacokinetic studies in healthy volunteers in which significant implications for clinical prescribing are discussed. -Studies focusing on the application of drug delivery technology in healthcare. -Short communications and case study reports that meet the above criteria will also be considered. Additional digital features (including animated abstracts, video abstracts, slide decks, audio slides, instructional videos, infographics, podcasts and animations) can be published with articles; these are designed to increase the visibility, readership and educational value of the journal’s content. In addition, articles published in Clinical Drug Investigation may be accompanied by plain language summaries to assist readers who have some knowledge, but non in-depth expertise in, the area to understand important medical advances.
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