The WASP/WAVE Protein Family in Breast Cancer and Their Role in the Metastatic Cascade.

IF 2.6 4区医学 Q2 GENETICS & HEREDITY

Cancer Genomics & Proteomics Pub Date : 2025-03-01 DOI:10.21873/cgp.20495

Rhiannon Yannan Yu, Wen G Jiang, Tracey A Martin

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引用次数: 0

Abstract

The Wiskott-Aldrich syndrome protein (WASP) and the WASP family verprolin-homologous protein (WAVE) family are essential molecules that connect GTPases to the actin cytoskeleton, thereby controlling actin polymerisation through the actin-related protein 2/3 complex. This control is crucial for forming actin-based membrane protrusions necessary for cell migration and invasion. The elevated expression of WASP/WAVE proteins in invasive breast cancer cells highlights their significant role in promoting cell motility and invasion. This review summarises the discovery, structural properties, and activation mechanisms of WASP/WAVE proteins, focuses on the contribution of the WASP/WAVE family to breast cancer invasion and migration, particularly synthesises the results of nearly a decade of research in this field since 2015. By exploring promising therapeutic strategies for breast cancer, including small molecule inhibitors and biological agents, this review stresses the potential for developing anticancer drugs that target the WASP/WAVE family and associated pathways, intending to improve the prognosis for patients with metastatic breast cancer.

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乳腺癌中的WASP/WAVE蛋白家族及其在转移级联中的作用。

Wiskott-Aldrich综合征蛋白（WASP）和WASP家族verprolin同源蛋白（WAVE）家族是连接gtpase与肌动蛋白细胞骨架的重要分子，从而通过肌动蛋白相关蛋白2/3复合物控制肌动蛋白聚合。这种控制对于形成细胞迁移和侵袭所必需的肌动蛋白基膜突起至关重要。WASP/WAVE蛋白在侵袭性乳腺癌细胞中的表达升高，凸显了其在促进细胞运动和侵袭中的重要作用。本文综述了WASP/WAVE蛋白的发现、结构特性和激活机制，重点介绍了WASP/WAVE家族在乳腺癌侵袭和迁移中的作用，并综合了自2015年以来近十年来该领域的研究成果。通过探索有前景的乳腺癌治疗策略，包括小分子抑制剂和生物制剂，本综述强调了开发针对WASP/WAVE家族及其相关途径的抗癌药物的潜力，旨在改善转移性乳腺癌患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Genomics & Proteomics ONCOLOGY-GENETICS & HEREDITY

CiteScore

5.00

自引率

8.00%

发文量

期刊介绍： Cancer Genomics & Proteomics (CGP) is an international peer-reviewed journal designed to publish rapidly high quality articles and reviews on the application of genomic and proteomic technology to basic, experimental and clinical cancer research. In this site you may find information concerning the editorial board, editorial policy, issue contents, subscriptions, submission of manuscripts and advertising. The first issue of CGP circulated in January 2004. Cancer Genomics & Proteomics is a journal of the International Institute of Anticancer Research. From January 2013 CGP is converted to an online-only open access journal. Cancer Genomics & Proteomics supports (a) the aims and the research projects of the INTERNATIONAL INSTITUTE OF ANTICANCER RESEARCH and (b) the organization of the INTERNATIONAL CONFERENCES OF ANTICANCER RESEARCH.