A bio. tools collection of online resources for GPCR research.

IF 6.8 2区医学 Q1 PHARMACOLOGY & PHARMACY

British Journal of Pharmacology Pub Date : 2025-02-24 DOI:10.1111/bph.17461

Tõnis Laasfeld, Friederike Wunsch, Avgi E Apostolakou, Adrián García-Recio, Gáspár Pándy-Szekeres, Slawomir Filipek, Masha Y Niv, Jana Selent, David E Gloriam, Marcel Bermudez

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引用次数: 0

Abstract

G protein-coupled receptors are highly complex signal transduction proteins with many potential biomedical applications. Researchers from different fields work together to improve mechanistic understanding of GPCR function and to transfer that knowledge in order to advance therapeutic options. Due to the interdisciplinary nature of GPCR research, many databases and web tools with different types and levels of information are being developed to support scientists in sharing and analysing data. Here, we aim to give an overview of freely available online chemoinformatics and bioinformatics resources specifically designed to aid GPCR research. We compiled a dedicated domain on ELIXIR's bio. tools portal as a continuously updatable repository of GPCR-related online resources (https://bio.tools/t?domain=gpcr). This provides an up-to-date overview of available tools, rather than a static list representing only a snapshot in time. Furthermore, we give some recommendations for developing and using scientific online resources and briefly describe selected databases and web-based tools for GPCR research.

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来源期刊

British Journal of Pharmacology 医学-药学

CiteScore

15.40

自引率

12.30%

发文量

270

审稿时长

2.0 months

期刊介绍： The British Journal of Pharmacology (BJP) is a biomedical science journal offering comprehensive international coverage of experimental and translational pharmacology. It publishes original research, authoritative reviews, mini reviews, systematic reviews, meta-analyses, databases, letters to the Editor, and commentaries. Review articles, databases, systematic reviews, and meta-analyses are typically commissioned, but unsolicited contributions are also considered, either as standalone papers or part of themed issues. In addition to basic science research, BJP features translational pharmacology research, including proof-of-concept and early mechanistic studies in humans. While it generally does not publish first-in-man phase I studies or phase IIb, III, or IV studies, exceptions may be made under certain circumstances, particularly if results are combined with preclinical studies.