Curcumin supplementation combined with high intensity interval training modulates serum irisin and lipid profile in obese women: "A randomized double-blind clinical trial"

IF 1.4 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Contemporary Clinical Trials Communications Pub Date : 2025-02-21 DOI:10.1016/j.conctc.2025.101464

Bahram Jamali Gharakhanlou , Solmaz Babaei Bonab , Akram Amaghani , Mohammad Reza Shiri-Shahsavar

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引用次数: 0

Abstract

Background

Curcumin is the most widely known active substance of turmeric extract, which attributed numerous functional properties, including anti-inflammatory and cardioprotective properties. Inactivity and changes in lifestyle and subsequent overweight/obesity are becoming major health risk factors.

Objective

the aim of this study was to determine the effect of curcumin supplementation combined with high intensity interval trainings (HIIT) exercise on serum irisin and lipid profile in obese women.

Methods

40 inactive women (aged 30–35 years, and body mass index 30 and above) allocated in four groups (10 in each) as followed; curcumin (C), exercise plus curcumin (EC), placebo (P), and exercise plus placebo (EP). All subjects completed an eight-week HIIT program. The C and EC groups received one capsule containing 80 mg curcumin nanomicelle daily throughout study. Blood samples were taken in the beginning and after eight weeks to measure changes in the study variables (irisin and lipid profile). The ANCOVA and Bonferroni's post hoc test was used to compare variables between 4 groups and pairwise at a significance level of ≤0.05 using SPSS-22.

Results

The results revealed that mean serum irisin (p = 0.023), cholesterol (p = 0.019), triglyceride (p = 0.022), high-density lipoprotein (p = 0.009) and low-density lipoprotein (p = 0.011) were significantly changed in all intervention groups compared to the placebo group.

Conclusion

Based on these results, it can be concluded that HIIT training with curcumin consumption has a greater significancy on obesity reduction in women; Therefore, curcumin and HIIT exercise can be considered as a therapeutic approach to reduce the negative outcomes of obesity.

Clinical trial registry number

IRCT20141004019397N2, link.

Statement of significance

This study investigated the effects of curcumin supplementation combined with high-intensity interval training (HIIT) on human serum Irisin levels for the first time, in a clinical randomized trial. This suggests that HIIT training alongside curcumin consumption may be a promising therapeutic approach to reduce the negative health consequences of obesity in women.

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姜黄素补充联合高强度间歇训练调节肥胖妇女血清鸢尾素和脂质：“一项随机双盲临床试验”

姜黄素是姜黄提取物中最广为人知的活性物质，具有多种功能特性，包括抗炎和心脏保护特性。缺乏运动和生活方式的改变以及随之而来的超重/肥胖正在成为主要的健康风险因素。目的本研究的目的是确定姜黄素补充与高强度间歇训练（HIIT）运动对肥胖女性血清鸢尾素和血脂的影响。方法40名年龄在30 ~ 35岁，身体质量指数在30及以上的非运动女性分为4组（每组10人）；姜黄素(C)、运动加姜黄素（EC）、安慰剂(P)和运动加安慰剂（EP）。所有受试者都完成了为期8周的HIIT计划。在整个研究过程中，C组和EC组每天服用一粒含有80毫克姜黄素纳米粒的胶囊。在开始和八周后采集血液样本，以测量研究变量（鸢尾素和脂质谱）的变化。4组间变量比较采用ANCOVA和Bonferroni’s事后检验，两两比较采用SPSS-22，显著性水平≤0.05。结果与安慰剂组比较，各干预组患者血清鸢尾素（p = 0.023）、胆固醇（p = 0.019）、甘油三酯（p = 0.022）、高密度脂蛋白（p = 0.009）、低密度脂蛋白（p = 0.011）均有显著变化。结论HIIT训练加姜黄素摄入对女性减脂效果更显著；因此，姜黄素和HIIT运动可以被认为是一种减少肥胖负面结果的治疗方法。临床试验注册号：irct20141004019397n2，链接。本研究首次在一项临床随机试验中研究了姜黄素补充剂联合高强度间歇训练（HIIT）对人血清鸢尾素水平的影响。这表明HIIT训练与姜黄素摄入可能是一种有希望的治疗方法，可以减少女性肥胖对健康的负面影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Contemporary Clinical Trials Communications Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

2.70

自引率

6.70%

发文量

146

审稿时长

20 weeks

期刊介绍： Contemporary Clinical Trials Communications is an international peer reviewed open access journal that publishes articles pertaining to all aspects of clinical trials, including, but not limited to, design, conduct, analysis, regulation and ethics. Manuscripts submitted should appeal to a readership drawn from a wide range of disciplines including medicine, life science, pharmaceutical science, biostatistics, epidemiology, computer science, management science, behavioral science, and bioethics. Contemporary Clinical Trials Communications is unique in that it is outside the confines of disease specifications, and it strives to increase the transparency of medical research and reduce publication bias by publishing scientifically valid original research findings irrespective of their perceived importance, significance or impact. Both randomized and non-randomized trials are within the scope of the Journal. Some common topics include trial design rationale and methods, operational methodologies and challenges, and positive and negative trial results. In addition to original research, the Journal also welcomes other types of communications including, but are not limited to, methodology reviews, perspectives and discussions. Through timely dissemination of advances in clinical trials, the goal of Contemporary Clinical Trials Communications is to serve as a platform to enhance the communication and collaboration within the global clinical trials community that ultimately advances this field of research for the benefit of patients.