Intracluster correlation coefficients from cluster randomized trials conducted within the NCI Community Oncology Research Program (NCORP).

Journal of the National Cancer Institute. Monographs Pub Date : 2025-03-01 DOI:10.1093/jncimonographs/lgae048

Anna C Snavely, Heather J Gunn, Ju-Whei Lee, Stephanie L Pugh, William E Barlow, Eva Culakova, Kathryn B Arnold, Carol A Kittel, Sydney Smith, Bret M Hanlon, Angelina D Tan, Travis Dockter, David Zahrieh, Emily V Dressler

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引用次数: 0

Abstract

The intracluster correlation coefficient (ICC) measures the correlation of observations within clusters and is a key parameter for power and sample size calculations for cluster randomized trials (CRTs). To facilitate the design of future CRTs within the National Cancer Institute Community Oncology Research Program (NCORP), all studies from the NCORP website were reviewed to identify completed CRTs. ICCs for primary and secondary outcomes (when available) were ascertained from these trials and summarized in this article as a resource for future trial development. Although ICCs are relatively small for many outcome cluster combinations, that is not always the case, so consideration should always be given to the specific outcome of interest, trial design, and type of cluster when estimating an ICC to facilitate trial development.

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在NCI社区肿瘤研究计划（NCORP）中进行的群随机试验的群内相关系数。

群组内相关系数 (ICC) 衡量群组内观察结果的相关性，是群组随机试验 (CRT) 功率和样本量计算的关键参数。为便于在美国国立癌症研究所社区肿瘤学研究项目（NCORP）内设计未来的 CRT，我们对 NCORP 网站上的所有研究进行了审查，以确定已完成的 CRT。从这些试验中确定了主要和次要结果的 ICCs（如有），并在本文中进行了总结，作为未来试验开发的资源。虽然许多结果分组组合的 ICC 相对较小，但情况并非总是如此，因此在估算 ICC 以促进试验开发时，应始终考虑特定的相关结果、试验设计和分组类型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the National Cancer Institute. Monographs

CiteScore

6.30

自引率

0.00%

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