Breast cancer in a patient with neurofibromatosis type 1: A case report and review of literature.

IF 0.9 Q4 ONCOLOGY

Rare Tumors Pub Date : 2025-02-20 eCollection Date: 2025-01-01 DOI:10.1177/20363613251322866

Victor I Canice Nwagbara, John A Ashindoitiang, Theophilus Ipeh Ugbem, Dino N Magam, Chibuike M Meremikwu, Victor D Nnalue, Maurice E Asuquo

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Abstract

Neurofibromatosis 1 (NF1) represents a cluster of clinical features based on the National Institute of Health(NIH) diagnostic criteria. It is a multi-systemic disease with progressive features characterized by variable expression. NF1 is associated with an increased risk of malignancies including breast cancer. Presented was a 56 year old woman with a painless lump in the right breast in the past 15 months. Clinical evaluation revealed features of NF1 and an advanced right breast cancer. Histologic evaluation revealed an invasive ductal carcinoma and she was offered a right modified radical mastectomy. Due to clinical presentation with discrete lesions, NF1 may be diagnosed at presentation with malignancy. Clinicians are urged to be familiar with the subtle features of NF1 for early diagnosis that is largely clinical. Institution of early breast cancer surveillance in patients with NF1 is recommended for early diagnosis and improved outcomes.

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1型神经纤维瘤病合并乳腺癌1例报告及文献复习。

神经纤维瘤病1 （NF1）代表了基于美国国立卫生研究院（NIH）诊断标准的一组临床特征。它是一种多系统的进行性疾病，以表达变化为特征。NF1与包括乳腺癌在内的恶性肿瘤风险增加有关。提出了一个56岁的妇女，在过去的15个月在右乳房无痛性肿块。临床评估显示NF1和晚期右乳腺癌的特征。组织学检查显示为浸润性导管癌，她接受了右侧改良乳房根治术。由于临床表现为离散病变，NF1可能在表现为恶性肿瘤时被诊断。临床医生被敦促熟悉NF1的细微特征，以便在很大程度上进行临床早期诊断。建议对NF1患者进行早期乳腺癌监测，以便早期诊断和改善预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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