{"title":"Bacteriostatic and Immunomodulatory Effect of Xylocaine in the Context of <i>in Vitro</i> Bladder Epithelial Cell Infection.","authors":"John Kerr White, Yundi Yin, Soumitra Mohanty, Natalia Ferraz, Annelie Brauner","doi":"10.1021/acsbiomedchemau.4c00070","DOIUrl":null,"url":null,"abstract":"<p><p>The application of urinary catheters is associated with pain and discomfort. Several topical medications are available to ease catheter insertion, including xylocaine. Here we report that xylocaine, although not classified as an antibacterial agent, has bacteriostatic properties against both Gram-positive and Gram-negative etiological agents of urinary tract infections (UTIs). Xylocaine reduces the amount of biofilm formed by ESBL- and non-ESBL-producing <i>E. coli</i>. In addition, xylocaine possesses slight immunomodulatory properties in uroepithelial cells, and treatment of uroepithelial cells prior to infection reduces bacterial loads in the supernatant. In conclusion, xylocaine has multifaceted positive effects when used during the insertion of urinary catheters.</p>","PeriodicalId":29802,"journal":{"name":"ACS Bio & Med Chem Au","volume":"5 1","pages":"31-34"},"PeriodicalIF":3.8000,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843344/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Bio & Med Chem Au","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1021/acsbiomedchemau.4c00070","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/19 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The application of urinary catheters is associated with pain and discomfort. Several topical medications are available to ease catheter insertion, including xylocaine. Here we report that xylocaine, although not classified as an antibacterial agent, has bacteriostatic properties against both Gram-positive and Gram-negative etiological agents of urinary tract infections (UTIs). Xylocaine reduces the amount of biofilm formed by ESBL- and non-ESBL-producing E. coli. In addition, xylocaine possesses slight immunomodulatory properties in uroepithelial cells, and treatment of uroepithelial cells prior to infection reduces bacterial loads in the supernatant. In conclusion, xylocaine has multifaceted positive effects when used during the insertion of urinary catheters.
期刊介绍：
ACS Bio & Med Chem Au is a broad scope open access journal which publishes short letters comprehensive articles reviews and perspectives in all aspects of biological and medicinal chemistry. Studies providing fundamental insights or describing novel syntheses as well as clinical or other applications-based work are welcomed.This broad scope includes experimental and theoretical studies on the chemical physical mechanistic and/or structural basis of biological or cell function in all domains of life. It encompasses the fields of chemical biology synthetic biology disease biology cell biology agriculture and food natural products research nucleic acid biology neuroscience structural biology and biophysics.The journal publishes studies that pertain to a broad range of medicinal chemistry including compound design and optimization biological evaluation molecular mechanistic understanding of drug delivery and drug delivery systems imaging agents and pharmacology and translational science of both small and large bioactive molecules. Novel computational cheminformatics and structural studies for the identification (or structure-activity relationship analysis) of bioactive molecules ligands and their targets are also welcome. The journal will consider computational studies applying established computational methods but only in combination with novel and original experimental data (e.g. in cases where new compounds have been designed and tested).Also included in the scope of the journal are articles relating to infectious diseases research on pathogens host-pathogen interactions therapeutics diagnostics vaccines drug-delivery systems and other biomedical technology development pertaining to infectious diseases.
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