Re-evaluation of histopathological factors for the outcome of salivary duct carcinoma patients: A multi-institutional retrospective study of 240 cases in a Japanese cohort

IF 2.7 2区医学 Q2 PATHOLOGY

Human pathology Pub Date : 2025-01-01 DOI:10.1016/j.humpath.2025.105736

Kimihide Kusafuka , Eiji Nakatani , Satoshi Baba , Yoshifumi Arai , Matsuyoshi Maeda , Koji Yamanegi , Takayuki Murase , Hiroshi Inagaki , Yoshiro Otsuki , Kensuke Suzuki , Hiroshi Iwai , Yoshiaki Imamura , Shoji Yamanaka , Ichiro Ito , Midori Sato , Morito Kurata , Tsutomu Daa , Tomonori Kawasaki , Ryo Kawata , Yuri Tachibana , Makoto Suzuki

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引用次数: 0

Abstract

Aims

Salivary duct carcinoma (SDC) is a relatively common, high-grade salivary gland malignancy that can often occur as a carcinomatous component of carcinoma ex pleomorphic adenoma (CXPA). This study aimed to elucidate the histological factors which are related to the outcome of SDC.

Methods and results

We conducted a comprehensive histological review of 240 SDC cases and we analyzed the association between the histomorpholgical parameters and the clinical outcomes to identify new histological prognostic factors. The majority of cases involved the parotid glands (n = 197 cases). SDC showed a marked male predilection (M/F = 5.3:1), and the median age was 66 years-old. This study included 110 de novo cases and 130 CXPA cases. Multivariate analysis revealed that only the pathological stage was significantly associated with overall survival (OS), whereas previously reported histological parameters, such as poorly differentiated clusters, nuclear polymorphism, and mitotic index were not significantly associated with OS and progression-free survival (PFS). Vascular invasion (V [+]) was significantly associated with PFS, and lymphatic invasion was associated with late lymph node metastases. Even in the same pathological stage, V (+) cases always had the worse PFS than V (−) cases.

Conclusions

The histopathological review determined that as distant metastasis relapse was the most important prognostic factor in patients with SDC, V (+) status was also a significant outcome indicator.

查看原文本刊更多论文

对涎腺导管癌患者预后的组织病理学因素的重新评估：一项日本队列中240例病例的多机构回顾性研究。

目的：涎腺导管癌（SDC）是一种相对常见的高级别唾液腺恶性肿瘤，常作为癌性多形性腺瘤（CXPA）的癌性组成部分发生。本研究旨在阐明与SDC预后相关的组织学因素。方法与结果：我们对240例SDC病例进行了全面的组织学回顾，并分析了组织形态学参数与临床结局之间的关系，以发现新的组织学预后因素。大多数病例累及腮腺（197例）。SDC表现出明显的男性偏好（M/F=5.3:1），中位年龄66岁。本研究纳入110例新发病例和130例CXPA病例。多变量分析显示，只有病理分期与总生存期（OS）显著相关，而先前报道的组织学参数，如低分化簇，核多态性和有丝分裂指数与OS和无进展生存期（PFS）无显著相关性。血管浸润（V[+]）与PFS显著相关，淋巴浸润与晚期淋巴结转移相关。即使在同一病理阶段，V（+）病例的PFS也总是比V（-）病例差。结论：组织病理学检查确定，由于远处转移复发是SDC患者最重要的预后因素，V（+）状态也是一个重要的预后指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human pathology 医学-病理学

CiteScore

5.30

自引率

6.10%

发文量

206

审稿时长

21 days

期刊介绍： Human Pathology is designed to bring information of clinicopathologic significance to human disease to the laboratory and clinical physician. It presents information drawn from morphologic and clinical laboratory studies with direct relevance to the understanding of human diseases. Papers published concern morphologic and clinicopathologic observations, reviews of diseases, analyses of problems in pathology, significant collections of case material and advances in concepts or techniques of value in the analysis and diagnosis of disease. Theoretical and experimental pathology and molecular biology pertinent to human disease are included. This critical journal is well illustrated with exceptional reproductions of photomicrographs and microscopic anatomy.