MicroRNA-203 Expression as Potential Biomarker for Lupus Nephritis.

IF 2.1 Q2 UROLOGY & NEPHROLOGY

International Journal of Nephrology and Renovascular Disease Pub Date : 2025-02-17 eCollection Date: 2025-01-01 DOI:10.2147/IJNRD.S485409

Yuswanto Setyawan, Hani Susianti, Hermin Sulistyarti, Matthew Brian Khrisna, Dearikha Karina Mayashinta, Loeki Enggar Fitri, Nur Samsu

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引用次数: 0

Abstract

Introduction and purpose: Lupus nephritis (LN) is the main cause of morbidity and mortality in systemic lupus erythematosus (SLE) patients, therefore the discovery of new biomarkers, which are reliable for the diagnosis of NL is necessary. Various studies have reported alteration of some miRNAs expression in LN, that considered as biomarkers and/or therapeutic targets in LN. MicroRNA-203 has been associated with the development of nephritis in SLE patients, playing an important role in the initiation and progression of the disease, but research on circulating miRNA-203 expression in LN in clinical practice is still very limited. The aim of this study was to prove the role of microRNA-203 in LN.

Patients and methods: Serum was obtained from 40 participants consisting of 20 SLE patients and 20 LN patients. The diagnostic of SLE and LN was based on the ACR 1997 criteria. MicroRNA-203 expression was determined by real-time Polymerase Chain Reaction (PCR). Statistical analysis was performed with Mann-Whitney test.

Results: The expression of miRNA-203 in the SLE group was 1.66 (0.00-8.64) and in the NL group was 5.18 (0.25-49.84). There were significant differences in microRNA-203 expression between SLE and LN patients (p=0.003).

Conclusion: MicroRNA-203 expression might be associated with nephritis manifestations in SLE patients.

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MicroRNA-203表达作为狼疮肾炎的潜在生物标志物。

简介及目的：狼疮肾炎（Lupus nephroritis， LN）是系统性红斑狼疮（systemic Lupus erythematosus， SLE）患者发病和死亡的主要原因，因此有必要发现新的、可靠的生物标志物来诊断狼疮肾炎。各种研究报道了LN中一些mirna表达的改变，这些mirna被认为是LN的生物标志物和/或治疗靶点。MicroRNA-203与SLE患者肾炎的发生发展相关，在疾病的发生和发展中起着重要作用，但在临床实践中对LN中循环miRNA-203表达的研究仍然非常有限。本研究的目的是为了证明microRNA-203在LN中的作用。患者和方法：从40名参与者中获得血清，其中包括20名SLE患者和20名LN患者。SLE和LN的诊断基于ACR 1997标准。实时聚合酶链反应（real-time Polymerase Chain Reaction， PCR）检测MicroRNA-203的表达。采用Mann-Whitney检验进行统计学分析。结果：miRNA-203在SLE组的表达为1.66(0.00 ~ 8.64)，在NL组的表达为5.18（0.25 ~ 49.84）。SLE与LN患者microRNA-203表达差异有统计学意义（p=0.003）。结论：MicroRNA-203的表达可能与SLE患者肾炎的表现有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Nephrology and Renovascular Disease UROLOGY & NEPHROLOGY-

CiteScore

3.90

自引率

5.00%

发文量

审稿时长

16 weeks

期刊介绍： International Journal of Nephrology and Renovascular Disease is an international, peer-reviewed, open-access journal focusing on the pathophysiology of the kidney and vascular supply. Epidemiology, screening, diagnosis, and treatment interventions are covered as well as basic science, biochemical and immunological studies. In particular, emphasis will be given to: -Chronic kidney disease- Complications of renovascular disease- Imaging techniques- Renal hypertension- Renal cancer- Treatment including pharmacological and transplantation- Dialysis and treatment of complications of dialysis and renal disease- Quality of Life- Patient satisfaction and preference- Health economic evaluations. The journal welcomes submitted papers covering original research, basic science, clinical studies, reviews & evaluations, guidelines, expert opinion and commentary, case reports and extended reports. The main focus of the journal will be to publish research and clinical results in humans but preclinical, animal and in vitro studies will be published where they shed light on disease processes and potential new therapies and interventions.