Synthesis and antibacterial activity of environmentally friendly sulfonium compounds

IF 2.6 4区医学 Q3 CHEMISTRY, MEDICINAL

Medicinal Chemistry Research Pub Date : 2025-01-18 DOI:10.1007/s00044-024-03341-w

Jing Li, Wenyang Chen, Xinrui Bi, Yue Lin, Chengcai Liu, Yan Sun, Guinan Shen

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Abstract

The abuse and overuse of antibacterial drugs have caused the increasing drug resistance of pathogenic bacteria, which threats human health and environmental health. Therefore the development of new environmentally friendly antibacterial drugs is of great urgency. The purpose of this study is to develop novel sulfonium compounds and evaluate their antibacterial activities. The sulfonium compounds were obtained by substitution reactions of methionine. The antimicrobial activities of the compounds were evaluated by measurement of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against S. aureus and E. coli. A total of fifteen sulfonium compounds were synthesized and all of them showed antibacterial activity that varied with the substitution chain length. These compounds were highly sensitive to S. aureus with the lowest MIC and MBC at 0.39 μmol/L and 1.56 μmol/L, respectively, which are lower than that of commercial quaternary ammonium compounds. An extra group of eight sulfonium compounds were also constructed to study the relationship between compound structures and their antibacterial abilities. A preferred structure with one longer hydrophobic alkyl chain at the amine position has been demonstrated for better antibacterial activity.

Methionine based sulfonium compound as environmentally friendly antibacterial agent.

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来源期刊

Medicinal Chemistry Research 医学-医药化学

CiteScore

4.70

自引率

3.80%

发文量

162

审稿时长

5.0 months

期刊介绍： Medicinal Chemistry Research (MCRE) publishes papers on a wide range of topics, favoring research with significant, new, and up-to-date information. Although the journal has a demanding peer review process, MCRE still boasts rapid publication, due in part, to the length of the submissions. The journal publishes significant research on various topics, many of which emphasize the structure-activity relationships of molecular biology.