Complementary Split-Ring Resonator for Non-Invasive Diagnosis of Carotid Artery Atherosclerosis: Towards Future in-Vivo Measurements

IF 5.6 4区医学 Q1 ENGINEERING, BIOMEDICAL

Irbm Pub Date : 2025-02-14 DOI:10.1016/j.irbm.2025.100883

Joséphine Dupeyron Masini , Frédérique Deshours , Georges Alquie , Rania Shahbaz , Sylvain Feruglio , Olivier Meyer , Dimitri Galayko , Hamid Kokabi , Jean-Michel Davaine

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Abstract

Objectives

The limited penetration depth of electromagnetic (EM) waves into biological tissues is a significant challenge for the use of microwave sensors in medical diagnostics. This study proposes a sensor based on a complementary split-ring resonator (CSRR) for the non-invasive detection of carotid atherosclerotic plaques, designed to be placed on the patient's neck.

Material and methods

The sensor employs a widened feed line and an optimized sensing area to concentrate the electric field and store a significant amount of energy within the biological tissue. Validation includes EM simulations and ex-vivo measurements on fresh animal tissues using monolayer and multilayer configurations to simulate human neck anatomy. A three-dimensional carotid artery model is also introduced to extend the analysis to deeper tissue layers and simulate different degrees of stenosis between 25% and 75%.

Results

The sensor demonstrates a sensitivity of 0.72% and a detection resolution of 14 MHz for a dielectric constant range from 1 to 52 in material measurements, which has contributed to enhancing the EM penetration depth in neck tissues. Simulation results for atherosclerotic plaques in the carotid artery revealed a frequency shift difference induced by stable and vulnerable plaques of around 1 to 2 MHz.

Conclusion

These findings highlight the sensor's potential for future use in the in- vivo diagnosis of carotid artery atherosclerosis.

Abstract Image

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来源期刊

Irbm ENGINEERING, BIOMEDICAL-

CiteScore

10.30

自引率

4.20%

发文量

审稿时长

57 days

期刊介绍： IRBM is the journal of the AGBM (Alliance for engineering in Biology an Medicine / Alliance pour le génie biologique et médical) and the SFGBM (BioMedical Engineering French Society / Société française de génie biologique médical) and the AFIB (French Association of Biomedical Engineers / Association française des ingénieurs biomédicaux). As a vehicle of information and knowledge in the field of biomedical technologies, IRBM is devoted to fundamental as well as clinical research. Biomedical engineering and use of new technologies are the cornerstones of IRBM, providing authors and users with the latest information. Its six issues per year propose reviews (state-of-the-art and current knowledge), original articles directed at fundamental research and articles focusing on biomedical engineering. All articles are submitted to peer reviewers acting as guarantors for IRBM''s scientific and medical content. The field covered by IRBM includes all the discipline of Biomedical engineering. Thereby, the type of papers published include those that cover the technological and methodological development in: -Physiological and Biological Signal processing (EEG, MEG, ECG…)- Medical Image processing- Biomechanics- Biomaterials- Medical Physics- Biophysics- Physiological and Biological Sensors- Information technologies in healthcare- Disability research- Computational physiology- …