Palladium-Catalyzed Difluorocarbene Transfer Synthesis of Diaryl Ketones from Iodoarene and Arylboronic Acid

IF 4.6 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2025-02-24 DOI:10.1039/d4qo02405b

Zhiyong Tan, Tingting Chen, Jiayi Shen, Jinbin Zhu, Weihong Zhong, Wei Guo

引用次数: 0

Abstract

Herein, we disclose a novel carbonylative Suzuki-Miyaura reaction for the synthesis of diaryl ketones via palladium-catalyzed difluorocarbene transfer. BrCF2CO2Et was employed as a safe and effective carbonyl surrogate. The CO was readily in situ generated from the reaction of H2O with intermediate PdII=CF2. The current protocol offers a pragmatic and efficient approach for the synthesis of a series of diaryl ketones with the yield up to 97%. The broad substrate scope and further synthetic application in drugs and functional compounds represent that this carbonylative reaction is a highly appealing strategy.

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在此，我们揭示了一种通过钯催化二氟碳转移合成二芳基酮的新型羰基化 Suzukii-Miyaura 反应。BrCF2CO2Et 被用作安全有效的羰基替代物。CO 很容易从 H2O 与中间体 PdII=CF2 的反应中就地生成。目前的方案为合成一系列二芳基酮提供了一种实用高效的方法，收率高达 97%。广泛的底物范围以及在药物和功能化合物中的进一步合成应用表明，这种羰基化反应是一种极具吸引力的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.