Anatomical zone and tissue type impacts the repeatability of quantitative MRI parameters and radiomic features for longitudinal monitoring of treatment response in the prostate.

IF 2 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Magnetic Resonance Materials in Physics, Biology and Medicine Pub Date : 2025-02-22 DOI:10.1007/s10334-025-01231-9

Yu-Feng Wang, Sirisha Tadimalla, Lois Holloway, Niluja Thiruthaneeswaran, Annette Haworth

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引用次数: 0

Abstract

Objective: To (1) establish the repeatability coefficient (%RC) of region of interest (ROI) and voxel-wise measurements of a comprehensive range of quantitative MRI (qMRI) parameters and radiomic features in the prostate, and (2) assess the impact of different tissue types (benign vs tumor) and anatomical zones (peripheral, PZ, and non-peripheral, nPZ) on the %RCs.

Methods: Test-retest qMRI was acquired in ten prostate cancer patients and six healthy volunteers. Parametric maps of apparent diffusion coefficient (ADC), diffusion coefficient (D), perfusion fraction (f), hypoxia score (HS), longitudinal relaxation time (T1), and observed transverse relaxation rate (R2*) were calculated. Fifty-nine radiomic feature maps were calculated from each of the parametric maps and T2-weighted images. The %RCs between tissue type and anatomical zones were compared using the Student's t test at 95% significance level.

Results: The %RC of ADC, D and HS, and up to 118 (out of all 413) radiomic features was significantly different between either anatomical zones, or between tumor and benign tissue, or both.

Conclusions: DWI-derived parameters and a portion of their radiomic features require %RCs to be established specifically for anatomical zones, tumor and benign tissues. The remaining qMRI parameters and features can have a single threshold for the whole prostate.

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目的目的：(1) 确定感兴趣区（ROI）和体素范围内对前列腺一系列定量 MRI（qMRI）参数和放射学特征测量的重复性系数（%RC）；(2) 评估不同组织类型（良性与肿瘤）和解剖区（外周、PZ 和非外周、nPZ）对重复性系数（%RC）的影响：方法：对 10 名前列腺癌患者和 6 名健康志愿者进行了重测 qMRI 采集。计算了表观扩散系数（ADC）、扩散系数（D）、灌注分数（f）、缺氧评分（HS）、纵向弛豫时间（T1）和观察到的横向弛豫速率（R2*）的参数图。根据每个参数图和 T2 加权图像计算出 59 个放射学特征图。在 95% 的显著性水平下，使用学生 t 检验比较组织类型和解剖区之间的%RC：结果：ADC、D和HS以及多达118个（全部413个中）放射学特征的%RC在解剖区之间、肿瘤和良性组织之间或两者之间存在显著差异：结论：DWI衍生参数及其部分放射学特征需要针对解剖区、肿瘤和良性组织建立%RC。其余的 qMRI 参数和特征可以对整个前列腺采用单一阈值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Magnetic Resonance Materials in Physics, Biology and Medicine 医学-核医学

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： MAGMA is a multidisciplinary international journal devoted to the publication of articles on all aspects of magnetic resonance techniques and their applications in medicine and biology. MAGMA currently publishes research papers, reviews, letters to the editor, and commentaries, six times a year. The subject areas covered by MAGMA include: advances in materials, hardware and software in magnetic resonance technology, new developments and results in research and practical applications of magnetic resonance imaging and spectroscopy related to biology and medicine, study of animal models and intact cells using magnetic resonance, reports of clinical trials on humans and clinical validation of magnetic resonance protocols.