A superoxide anion responsive and self-reporting fluorescent H2S donor for the treatment of diabetic wound

IF 7.1 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Free Radical Biology and Medicine Pub Date : 2025-02-21 DOI:10.1016/j.freeradbiomed.2025.02.026

Ning Zhang , Tengchuan Fu , Tao Li , Pengjie Zhong , Luoyi Li , Mingtao Peng , Zhenghao Li , Ling Zhang , Han Wang , Ping Hu , Yifei Lu , Mengyun Yao

{"title":"A superoxide anion responsive and self-reporting fluorescent H2S donor for the treatment of diabetic wound","authors":"Ning Zhang , Tengchuan Fu , Tao Li , Pengjie Zhong , Luoyi Li , Mingtao Peng , Zhenghao Li , Ling Zhang , Han Wang , Ping Hu , Yifei Lu , Mengyun Yao","doi":"10.1016/j.freeradbiomed.2025.02.026","DOIUrl":null,"url":null,"abstract":"<div><div>Superoxide anion (O2•−) not only serves as a critical precursor for numerous damaging reactive oxygen species (ROS), but also is implicated in a variety of diseases, including cancer, cardiovascular disorders, and diabetes. Consequently, reducing the levels of superoxide anions and alleviating oxidative stress are of paramount importance. Conversely, hydrogen sulfide (H2S), recognized as a significant biological signaling molecule, plays vital roles in protecting mammalian cells from oxidative damage and promoting tissue regeneration. In this study, we reported a novel superoxide anion-responsive H2S donor (HSD-SO-B) designed to scavenge O2•− and produce H2S concurrently. This H2S donor exhibits several advantages: (1) rapid response to superoxide anions (O2•−) with remarkable selectivity over competing species (2) generating H2S while scavenging superoxide anions (3) producing ratiometric fluorescence for both visualization and quantification of H2S release. Moreover, this O2•−-responsive, self-immolative fluorescent H2S donor has shown significant therapeutic and reparative effects on the diabetic wound model in mice.</div></div>","PeriodicalId":12407,"journal":{"name":"Free Radical Biology and Medicine","volume":"231 ","pages":"Pages 109-119"},"PeriodicalIF":7.1000,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Free Radical Biology and Medicine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0891584925001091","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Superoxide anion (O₂^•−) not only serves as a critical precursor for numerous damaging reactive oxygen species (ROS), but also is implicated in a variety of diseases, including cancer, cardiovascular disorders, and diabetes. Consequently, reducing the levels of superoxide anions and alleviating oxidative stress are of paramount importance. Conversely, hydrogen sulfide (H₂S), recognized as a significant biological signaling molecule, plays vital roles in protecting mammalian cells from oxidative damage and promoting tissue regeneration. In this study, we reported a novel superoxide anion-responsive H₂S donor (HSD-SO-B) designed to scavenge O₂^•− and produce H₂S concurrently. This H₂S donor exhibits several advantages: (1) rapid response to superoxide anions (O₂^•−) with remarkable selectivity over competing species (2) generating H₂S while scavenging superoxide anions (3) producing ratiometric fluorescence for both visualization and quantification of H₂S release. Moreover, this O₂^•−-responsive, self-immolative fluorescent H₂S donor has shown significant therapeutic and reparative effects on the diabetic wound model in mice.

Abstract Image

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Free Radical Biology and Medicine 医学-内分泌学与代谢

CiteScore

14.00

自引率

4.10%

发文量

850

审稿时长

22 days

期刊介绍： Free Radical Biology and Medicine is a leading journal in the field of redox biology, which is the study of the role of reactive oxygen species (ROS) and other oxidizing agents in biological systems. The journal serves as a premier forum for publishing innovative and groundbreaking research that explores the redox biology of health and disease, covering a wide range of topics and disciplines. Free Radical Biology and Medicine also commissions Special Issues that highlight recent advances in both basic and clinical research, with a particular emphasis on the mechanisms underlying altered metabolism and redox signaling. These Special Issues aim to provide a focused platform for the latest research in the field, fostering collaboration and knowledge exchange among researchers and clinicians.