Epigenetic marvels: exploring the landscape of colorectal cancer treatment through cutting-edge epigenetic-based drug strategies.

IF 4.8 2区医学 Q1 GENETICS & HEREDITY

Clinical Epigenetics Pub Date : 2025-02-22 DOI:10.1186/s13148-025-01844-w

Azar Tahghighi, Effat Seyedhashemi, Javad Mohammadi, Arash Moradi, Aria Esmaeili, Majid Pornour, Kimia Jafarifar, Shahla Mohammad Ganji

{"title":"Epigenetic marvels: exploring the landscape of colorectal cancer treatment through cutting-edge epigenetic-based drug strategies.","authors":"Azar Tahghighi, Effat Seyedhashemi, Javad Mohammadi, Arash Moradi, Aria Esmaeili, Majid Pornour, Kimia Jafarifar, Shahla Mohammad Ganji","doi":"10.1186/s13148-025-01844-w","DOIUrl":null,"url":null,"abstract":"<p><p>Epigenetics is currently considered the investigation of inheritable changes in gene expression that do not rely on DNA sequence alteration. Significant epigenetic procedures are involved, such as DNA methylations, histone modifications, and non-coding RNA actions. It is confirmed through several investigations that epigenetic changes are associated with the formation, development, and metastasis of various cancers, such as colorectal cancer (CRC). The difference between epigenetic changes and genetic mutations is that the former could be reversed or prevented; therefore, cancer treatment and prevention could be achieved by restoring abnormal epigenetic events within the neoplastic cells. These treatments, consequently, cause the anti-tumour effects augmentation, drug resistance reduction, and host immune response stimulation. In this article, we begin our survey by exploring basic epigenetic mechanisms to understand epigenetic tools and strategies for treating colorectal cancer in monotherapy and combination with chemotherapy or immunotherapy.</p>","PeriodicalId":10366,"journal":{"name":"Clinical Epigenetics","volume":"17 1","pages":"34"},"PeriodicalIF":4.8000,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847397/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Epigenetics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s13148-025-01844-w","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}

引用次数: 0

Abstract

Epigenetics is currently considered the investigation of inheritable changes in gene expression that do not rely on DNA sequence alteration. Significant epigenetic procedures are involved, such as DNA methylations, histone modifications, and non-coding RNA actions. It is confirmed through several investigations that epigenetic changes are associated with the formation, development, and metastasis of various cancers, such as colorectal cancer (CRC). The difference between epigenetic changes and genetic mutations is that the former could be reversed or prevented; therefore, cancer treatment and prevention could be achieved by restoring abnormal epigenetic events within the neoplastic cells. These treatments, consequently, cause the anti-tumour effects augmentation, drug resistance reduction, and host immune response stimulation. In this article, we begin our survey by exploring basic epigenetic mechanisms to understand epigenetic tools and strategies for treating colorectal cancer in monotherapy and combination with chemotherapy or immunotherapy.

查看原文本刊更多论文

表观遗传学奇迹：通过基于表观遗传学的前沿药物策略探索结直肠癌治疗的前景。

表观遗传学目前被认为是不依赖于DNA序列改变的基因表达的可遗传变化的研究。重要的表观遗传过程涉及，如DNA甲基化，组蛋白修饰和非编码RNA的作用。通过多项研究证实，表观遗传变化与各种癌症的形成、发展和转移有关，如结直肠癌（CRC）。表观遗传变化和基因突变的区别在于前者是可以逆转或预防的；因此，癌症的治疗和预防可以通过恢复肿瘤细胞内的异常表观遗传事件来实现。因此，这些治疗可以增强抗肿瘤作用，降低耐药性，刺激宿主免疫反应。在本文中，我们从探索基本的表观遗传学机制开始，以了解单药治疗和联合化疗或免疫治疗治疗结直肠癌的表观遗传学工具和策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical Epigenetics ONCOLOGY-

自引率

5.30%

发文量

150

期刊介绍： Clinical Epigenetics, the official journal of the Clinical Epigenetics Society, is an open access, peer-reviewed journal that encompasses all aspects of epigenetic principles and mechanisms in relation to human disease, diagnosis and therapy. Clinical trials and research in disease model organisms are particularly welcome.