{"title":"CaCO3 Microparticle-Based Carriers: Optimization of BSA Loading by Coprecipitation","authors":"L. Biny, D. Kalenichenko, I. Nabiev, A. Sukhanova","doi":"10.1134/S1063778824100041","DOIUrl":null,"url":null,"abstract":"<p>Oncological diseases, constituting a major global cause of death, require more selective treatments to minimize side effects. Immunotherapy using antibodies targeting immune checkpoints is a promising approach, but it is limited by poor tumor penetration and treatment resistance of cancer cells. The use of biocompatible and biodegradable calcium carbonate microparticles as drug carriers offers a solution due to their capacity for encapsulation of biomolecules and control of their release, which increase the therapeutic efficacy while reducing side effects. Our study was aimed at optimizing the synthesis of calcium carbonate microparticles and improving the loading of bovine serum albumin, used as a model protein, into them by means of coprecipitation. The approaches developed here make it possible to obtain protein carriers with advanced morphological characteristics and with a loading efficiency of more than 90%.</p>","PeriodicalId":728,"journal":{"name":"Physics of Atomic Nuclei","volume":"87 11","pages":"1736 - 1739"},"PeriodicalIF":0.3000,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physics of Atomic Nuclei","FirstCategoryId":"101","ListUrlMain":"https://link.springer.com/article/10.1134/S1063778824100041","RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHYSICS, NUCLEAR","Score":null,"Total":0}
引用次数: 0
Abstract
Oncological diseases, constituting a major global cause of death, require more selective treatments to minimize side effects. Immunotherapy using antibodies targeting immune checkpoints is a promising approach, but it is limited by poor tumor penetration and treatment resistance of cancer cells. The use of biocompatible and biodegradable calcium carbonate microparticles as drug carriers offers a solution due to their capacity for encapsulation of biomolecules and control of their release, which increase the therapeutic efficacy while reducing side effects. Our study was aimed at optimizing the synthesis of calcium carbonate microparticles and improving the loading of bovine serum albumin, used as a model protein, into them by means of coprecipitation. The approaches developed here make it possible to obtain protein carriers with advanced morphological characteristics and with a loading efficiency of more than 90%.
期刊介绍：
Physics of Atomic Nuclei is a journal that covers experimental and theoretical studies of nuclear physics: nuclear structure, spectra, and properties; radiation, fission, and nuclear reactions induced by photons, leptons, hadrons, and nuclei; fundamental interactions and symmetries; hadrons (with light, strange, charm, and bottom quarks); particle collisions at high and superhigh energies; gauge and unified quantum field theories, quark models, supersymmetry and supergravity, astrophysics and cosmology.
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