Visible-light induced three component radical cascade 1,2-dialkylation of alkenes to access alcohols

IF 4.6 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2025-02-22 DOI:10.1039/d5qo00080g

Yu-Zhao Wang, Di-Di Tang, Han-Yue Zhang, Xiao-Yue Ma, De-Hua Xing, Chenjiang Liu, Yu Xia, Yan Li

引用次数: 0

Abstract

Visible-light mediated 1,2- dicarbofunctionalization of alkenes provided a powerful tool for the synthesis of structurally complicated and diverse molecules from simple precursors in one step. In this paper, a photo-catalyzed three-component 1,2-alkylation of alkenes with alkylboronic pinacol esters (APEs) and aldehydes have been accomplished. This transition-metal-free protocol provided a clean and efficient manner to access secondary alcohols with wide substrate scope compatibility and good functional group tolerance, and allowed a variety of alkenes, APEs and aldehydes to be transformed to the desired products in moderate to good yields under metal free conditions. Mechanism studies disclosed that this transformation may be involved a radical addition and radical-radical cross coupling process.

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.