A narrative review of epigenetic marker in H3K27ac and its emerging potential as a therapeutic target in cancer.

IF 3 4区医学 Q2 GENETICS & HEREDITY

Epigenomics Pub Date : 2025-03-01 Epub Date: 2025-02-21 DOI:10.1080/17501911.2025.2460900

Meizi Zhu, Xuejin Lu, Danhong Wang, Jinhu Ma, Yi Wang, Rui Wang, Hongye Wang, Wenhui Cheng, Yaling Zhu

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引用次数: 0

Abstract

Histone acetylation, particularly H3 K27 acetylation (H3K27ac), is a critical post-translational modification that regulates chromatin structure and gene expression, which plays a significant role in various cancers, including breast, colon, lung, hepatocellular, and prostate cancer. However, the mechanisms of H3K27ac in tumorigenesis are not yet comprehensive, especially its epigenetic mechanisms. This review endeavors to discuss findings on the involvement of H3K27ac in carcinogenesis within the past 5 years through a literature search using academic databases such as Web of Science. Firstly, we provide an overview of the diverse landscape of histone modifications, emphasizing the distinctive characteristics and critical significance of H3K27ac. Secondly, we summarize and compare advanced high-throughput sequencing technologies that have been utilized in the construction of the H3K27ac epigenetic map. Thirdly, we elucidate the role of H3K27ac in mediating gene transcription. Fourthly, we venture into the potential molecular mechanism of H3K27ac in cancer development. Finally, we engage in discussing future therapeutic approaches in oncology, with a spotlight on strategies that harness the potential of H3K27 modifications. In conclusion, this review comprehensively summarizes the characteristics of H3K27ac and underscores its pivotal role in cancer, providing valuable insights into its potential as a therapeutic target for cancer intervention.

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H3K27ac的表观遗传标记及其作为癌症治疗靶点的潜力的叙述性综述。

组蛋白乙酰化，特别是H3K27乙酰化（H3K27ac）是一种重要的翻译后修饰，可调节染色质结构和基因表达，在乳腺癌、结肠癌、肺癌、肝细胞癌和前列腺癌等多种癌症中发挥重要作用。然而，H3K27ac在肿瘤发生中的作用机制尚不全面，尤其是其表观遗传机制。本文通过对Web of Science等学术数据库的文献检索，试图讨论在过去5年中关于H3K27ac参与癌变的发现。首先，我们概述了组蛋白修饰的多样性，强调了H3K27ac的独特特征和关键意义。其次，总结比较了目前用于构建H3K27ac表观遗传图谱的先进高通量测序技术。第三，我们阐明了H3K27ac在介导基因转录中的作用。第四，我们探索了H3K27ac在癌症发展中的潜在分子机制。最后，我们讨论了肿瘤未来的治疗方法，重点关注利用H3K27修饰潜力的策略。总之，本综述全面总结了H3K27ac的特征，强调了其在癌症中的关键作用，为其作为癌症干预治疗靶点的潜力提供了有价值的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Epigenomics GENETICS & HEREDITY-

CiteScore

5.80

自引率

2.60%

发文量

审稿时长

>12 weeks

期刊介绍： Epigenomics provides the forum to address the rapidly progressing research developments in this ever-expanding field; to report on the major challenges ahead and critical advances that are propelling the science forward. The journal delivers this information in concise, at-a-glance article formats – invaluable to a time constrained community. Substantial developments in our current knowledge and understanding of genomics and epigenetics are constantly being made, yet this field is still in its infancy. Epigenomics provides a critical overview of the latest and most significant advances as they unfold and explores their potential application in the clinical setting.