{"title":"Bilateral Breast Cancer.","authors":"Keiichiro Tada","doi":"10.1177/00031348251323713","DOIUrl":null,"url":null,"abstract":"<p><p>This article is a review of the characteristics of bilateral breast cancer (BBC). Synchronous bilateral breast cancer (SBBC) and metachronous bilateral breast cancer (MBBC) account for 2.9-3.9% and 4.1-4.6% of all new breast cancer cases, respectively. The risk factors for SBBC include older patient age and lobular histology. On the other hand, younger age, lobular histology, and positive family history (or genetic factors) are the risk factors for MBBC. Contralateral prophylactic mastectomy in patients with mutations in the <i>BRCA1/2</i> genes has been reported to increase survival rates. The prognosis of patients with SBBC is worse than the prognosis of patients with unilateral breast cancer (UBC). The prognosis of patients with MBBC compared to patients with UBC remains undetermined because the ages of patients and the intervals between the occurrence of two primary breast cancers appear to have a major impact on survival outcomes. The differences between SBBC and MBBC need clarification to increase our understanding of BBCs.</p>","PeriodicalId":7782,"journal":{"name":"American Surgeon","volume":" ","pages":"31348251323713"},"PeriodicalIF":1.0000,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Surgeon","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/00031348251323713","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"SURGERY","Score":null,"Total":0}
引用次数: 0
Abstract
This article is a review of the characteristics of bilateral breast cancer (BBC). Synchronous bilateral breast cancer (SBBC) and metachronous bilateral breast cancer (MBBC) account for 2.9-3.9% and 4.1-4.6% of all new breast cancer cases, respectively. The risk factors for SBBC include older patient age and lobular histology. On the other hand, younger age, lobular histology, and positive family history (or genetic factors) are the risk factors for MBBC. Contralateral prophylactic mastectomy in patients with mutations in the BRCA1/2 genes has been reported to increase survival rates. The prognosis of patients with SBBC is worse than the prognosis of patients with unilateral breast cancer (UBC). The prognosis of patients with MBBC compared to patients with UBC remains undetermined because the ages of patients and the intervals between the occurrence of two primary breast cancers appear to have a major impact on survival outcomes. The differences between SBBC and MBBC need clarification to increase our understanding of BBCs.
期刊介绍：
The American Surgeon is a monthly peer-reviewed publication published by the Southeastern Surgical Congress. Its area of concentration is clinical general surgery, as defined by the content areas of the American Board of Surgery: alimentary tract (including bariatric surgery), abdomen and its contents, breast, skin and soft tissue, endocrine system, solid organ transplantation, pediatric surgery, surgical critical care, surgical oncology (including head and neck surgery), trauma and emergency surgery, and vascular surgery.
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