Tumor infiltrating lymphocytes in primary melanoma are associated with a better prognosis.

IF 2.7 3区医学 Q1 SURGERY

American journal of surgery Pub Date : 2025-02-08 DOI:10.1016/j.amjsurg.2025.116243

Steven L Morrison, Gang Han, Faith Elenwa, Stanley P Leong, Mohammed Kashani-Sabet, Barbara Pockaj, Heidi E Kosiorek, Richard L White, Jonathan S Zager, Jane L Messina, Vernon Sondak, Cristina O'Donoghue, John Harrison Howard, Schlomo Schneebaum, Roger Olofsson Bagge, Jukes P Namm, Carlos Garberoglio, Eli Avisar, Graham Fowler, Dale Han, John Vetto

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引用次数: 0

Abstract

Background: The relationship between tumor infiltrating lymphocytes (TIL) and survival in melanoma is poorly understood. We present a large multicenter study assessing the association between TIL and survival.

Methods: The Sentinel Lymph Node Working Group database was queried from 1993 to 2024 for cases with known TIL and survival data. TIL was analyzed dichotomously and stratified as non-brisk, brisk, and absent. Clinicopathologic factors were correlated with melanoma-specific survival (MSS), overall survival (OS), and recurrence-free survival (RFS).

Results: Among 4957 patients, TIL was present in 3980 (80.2 %) of patients. TIL was prognostic of MSS (p = 0.0033), OS (p = 0.0053), and RFS (p = 0.0011). In the stratified analysis, brisk TIL was more strongly associated with MSS, OS, and RFS than non-brisk TIL (all p < 0.04). Among patients with a positive sentinel lymph node, TIL was prognostic of MSS, OS, and RFS (all p < 0.03).

Conclusions: TIL is strongly predictive of survival in melanoma and may be useful in risk stratification when deciding whether risks of adjuvant therapy outweigh benefits for certain patients.

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原发性黑色素瘤浸润淋巴细胞预后较好。

背景：肿瘤浸润淋巴细胞（TIL）与黑色素瘤存活之间的关系尚不清楚。我们提出了一项大型多中心研究，评估TIL与生存之间的关系。方法：查询1993年至2024年前哨淋巴结工作组数据库中已知TIL和生存数据的病例。对TIL进行二分类和分层，分为不活跃、活跃和不存在。临床病理因素与黑色素瘤特异性生存期（MSS）、总生存期（OS）和无复发生存期（RFS）相关。结果：4957例患者中有3980例（80.2%）存在TIL。直到预后MSS (p = 0.0033),操作系统(p = 0.0053), RFS (p = 0.0011)。在分层分析中，与非快速TIL相比，快速TIL与MSS、OS和RFS的相关性更强（均为p）。结论：TIL可强烈预测黑色素瘤患者的生存，在确定某些患者辅助治疗的风险是否大于获益时，可能有助于进行风险分层。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of surgery 医学-外科

CiteScore

5.00

自引率

6.70%

发文量

570

审稿时长

56 days

期刊介绍： The American Journal of Surgery® is a peer-reviewed journal designed for the general surgeon who performs abdominal, cancer, vascular, head and neck, breast, colorectal, and other forms of surgery. AJS is the official journal of 7 major surgical societies* and publishes their official papers as well as independently submitted clinical studies, editorials, reviews, brief reports, correspondence and book reviews.