Ultra-sensitive hemoglobin sensing empowered by momentum-mismatch-driven quasi-bound states in the continuum

IF 2.3 3区物理与天体物理 Q2 PHYSICS, MULTIDISCIPLINARY

Physics Letters A Pub Date : 2025-02-19 DOI:10.1016/j.physleta.2025.130370

Shuaiqi Huang, Canxin Zhan, Yunyi Shan, Yingxian Li, Wenchuang Chen, Huiqing Dai, Keyin Cai, Jun Chen, Weilin Cai, Yuqing Su, Gengyan Chen, Feng Wu

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Abstract

As one of the most vital proteins in blood, hemoglobin plays an important role in the diagnosis and treatment of diverse diseases, such as anemia and leukemia. In this paper, we leverage a momentum-mismatch-driven quasi-bound state in the continuum (quasi-BIC) in a resonant grating waveguide structure to achieve ultra-sensitive hemoglobin sensing. Empowered by the extraordinary resonant feature of the momentum-mismatch-driven quasi-BIC, the optimized resolution for hemoglobin sensing reaches the order of 10⁻³ g/L. Besides, the maximum Q factor and figure of merit reach the order of 10³ and 10⁻¹ L/g, respectively. Our work provides a practicable route, well within current experimental conditions, to achieving ultra-sensitive hemoglobin sensing. These results would possess applications in the diagnosis and treatment of hemoglobin-related diseases.

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来源期刊

Physics Letters A 物理-物理：综合

CiteScore

5.10

自引率

3.80%

发文量

493

审稿时长

30 days

期刊介绍： Physics Letters A offers an exciting publication outlet for novel and frontier physics. It encourages the submission of new research on: condensed matter physics, theoretical physics, nonlinear science, statistical physics, mathematical and computational physics, general and cross-disciplinary physics (including foundations), atomic, molecular and cluster physics, plasma and fluid physics, optical physics, biological physics and nanoscience. No articles on High Energy and Nuclear Physics are published in Physics Letters A. The journal''s high standard and wide dissemination ensures a broad readership amongst the physics community. Rapid publication times and flexible length restrictions give Physics Letters A the edge over other journals in the field.