Qian Xiao, Qiuyu Feng, Martin K. Rutter, Gali Albalak, Heming Wang, Raymond Noordam
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引用次数: 0
Abstract
Aims/hypothesis
Growing evidence suggests that timing may be an important aspect of physical activity that influences cardiometabolic health. However, the current literature is inconclusive regarding the time of day that physical activity offers the greatest metabolic advantages. We investigated associations between hourly physical activity levels and diabetes mellitus and glycaemic biomarkers in a cross-sectional and nationally representative sample of US adults.
Methods
We studied 7074 adults (mean age 48 years; 52% women) from the National Health and Nutrition Examination Survey (2011–2014). Physical activity was measured by actigraphy. A monitor-independent movement summary (MIMS) unit was used to derive the total activity level (divided into quintiles) for hourly windows that were defined relative to sleep timing and according to clock time. The primary outcome was prevalent diabetes, and secondary outcomes included fasting glucose, fasting insulin, HOMA-IR and 2 h OGTT results.
Results
Physical activity levels in late morning and late afternoon were associated with lower adjusted odds of diabetes. Specifically, in late morning (8:01–9:00 h after the sleep midpoint), the highest quintile of activity was associated with a 35% decrease (OR 0.65; 95% CI 0.44, 0.96) in the odds of diabetes when compared with the lowest quintile, while in late afternoon (11:01–17:00 h after the sleep midpoint), the highest quintiles were associated with 56% and 36% lower odds (OR 0.44; 95% CI 0.29, 0.69 and OR 0.64; 95% CI 0.43, 0.95). Higher night-time activity was associated with higher odds of diabetes. Similar patterns of results were observed with OGTT data and across subgroups of age, gender, race/ethnicity, chronotype and sleep duration.
Conclusions/interpretation
Our findings suggest that the timing of physical activity may modulate its metabolic effects.
目的/假设越来越多的证据表明，时间可能是影响心脏代谢健康的体育活动的一个重要方面。然而，目前的文献对一天中体育活动提供最大代谢优势的时间尚无定论。我们在美国成年人的横断面和全国代表性样本中调查了每小时体力活动水平与糖尿病和血糖生物标志物之间的关系。方法研究7074例成人(平均年龄48岁；来自全国健康和营养检查调查（2011-2014年）的52%妇女)。通过活动记录仪测量身体活动。一个独立于监测器的运动总结（MIMS）单元用于得出每小时窗口的总活动水平（分为五分位数），这些窗口是根据睡眠时间和时钟时间定义的。主要结局是糖尿病，次要结局包括空腹血糖、空腹胰岛素、HOMA-IR和2小时OGTT结果。结果上午晚些时候和下午晚些时候的体力活动水平与较低的糖尿病调整几率相关。具体来说，在上午晚些时候（睡眠中点后8:01-9:00），活动最高的五分位数与35%的下降相关(OR 0.65；95% CI 0.44, 0.96)，而在下午晚些时候（睡眠中点后11:01-17:00小时），最高的五分位数与56%和36%的几率降低相关(OR 0.44；95% CI 0.29, 0.69, OR 0.64；95% ci 0.43, 0.95)。夜间活动越频繁，患糖尿病的几率越高。OGTT数据和年龄、性别、种族/民族、睡眠类型和睡眠时间的亚组也观察到类似的结果模式。结论/解释：我们的研究结果表明，体育活动的时间可能会调节其代谢作用。图形抽象
期刊介绍：
Diabetologia, the authoritative journal dedicated to diabetes research, holds high visibility through society membership, libraries, and social media. As the official journal of the European Association for the Study of Diabetes, it is ranked in the top quartile of the 2019 JCR Impact Factors in the Endocrinology & Metabolism category. The journal boasts dedicated and expert editorial teams committed to supporting authors throughout the peer review process.
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