Social cognition profile in early Huntington disease: Insight from neuropsychological assessment and structural neuroimaging.

IF 2.1 Q3 NEUROSCIENCES
Journal of Huntington's disease Pub Date : 2024-11-01 Epub Date: 2024-11-04 DOI:10.1177/18796397241291730
Marie Caillaud, Mickael Laisney, Alexandre Bejanin, Harmony Duclos, Clarisse Scherer-Gagou, Adriana Prundean, Dominique Bonneau, Francis Eustache, Christophe Verny, Béatrice Desgranges, Philippe Allain
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Abstract

Background: Huntington's disease (HD) is traditionally associated with motor, cognitive, and neuropsychiatric symptoms. Recent observations suggest that disturbances in social cognition may feature prominently in HD, potentially contributing to behavioral challenges.

Objective: This study aims to explore the onset and neural mechanisms underlying social cognition disturbances in HD, which are not yet well understood despite increasing recognition of these symptoms.

Methods: This study compared 20 individuals in the early stages of HD with 20 healthy controls across a range of cognitive tests, in-depth social cognition assessments, and structural MRI evaluations.

Results: The findings revealed alterations in various aspects of social cognition, particularly cognitive and affective Theory of Mind, in the early HD group. Some of these alterations correlated with the neurodegeneration of the striatum (caudate), suggesting that social cognition deficits may serve as early indicators of disease progression.

Conclusions: This research underscores the importance of integrating social cognition evaluations into the clinical assessment of HD and hints at a complex interplay between these deficits and the broader neuropsychological impact of the disease. The results thus advocate for a more holistic approach to understanding and managing HD, considering the potential interdependencies between social cognition and other cognitive functions.

早期亨廷顿病的社会认知概况:来自神经心理学评估和结构神经影像学的见解。
背景:亨廷顿舞蹈病(HD)传统上与运动、认知和神经精神症状相关。最近的观察表明,社会认知障碍可能在HD中表现突出,可能导致行为挑战。目的:本研究旨在探讨HD患者社会认知障碍的发病和神经机制,尽管人们对这些症状的认识越来越多,但对这些症状的认识尚不清楚。方法:本研究将20名早期HD患者与20名健康对照者进行了一系列认知测试、深度社会认知评估和结构MRI评估。结果:研究结果揭示了早期HD组在社会认知的各个方面的变化,特别是认知和情感心理理论。其中一些改变与纹状体(尾状体)的神经变性相关,表明社会认知缺陷可能是疾病进展的早期指标。结论:本研究强调了将社会认知评估纳入HD临床评估的重要性,并暗示了这些缺陷与该疾病更广泛的神经心理影响之间的复杂相互作用。因此,考虑到社会认知和其他认知功能之间潜在的相互依赖性,研究结果提倡采用更全面的方法来理解和管理HD。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.80
自引率
9.70%
发文量
60
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