{"title":"Role of femoral intima-media thickness in risk prediction and assessment of severity of coronary artery disease.","authors":"Atul Kaushik, Surendra Patel, Sourabh Goswami, Pawan Garg, Akhil Dhanesh Goel, Danishwar Meena, Madhusudan Katti, Anupam Das, Rahul Choudhary, Surender Deora, Alok Kumar Sharma","doi":"10.1007/s12055-024-01824-4","DOIUrl":null,"url":null,"abstract":"<p><strong>Background/objective: </strong>Atherosclerosis is a systemic multifocal disease which most commonly involves branching points of the large and medium-sized arteries. The carotid intima-media thickness (c-IMT) is an established marker for increased cardiovascular risk and cerebrovascular disease. In this study, we aimed to establish the role of femoral intima-media thickness (FIMT) in predicting cardiovascular risk in angiographically confirmed patients of coronary artery disease (CAD) when compared with apparently healthy patients (having normal coronary angiogram).</p><p><strong>Methods: </strong>A total of 114 consecutive patients presented at our institute with symptoms of CAD who underwent coronary angiogram were included in the study. After the coronary angiogram, patients were divided into three groups, group A having normal coronary angiogram, group B having CAD with a synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) score of more than 22, and group C having CAD with a SYNTAX score of 22 or less. The Doppler ultrasound of the bilateral femoral artery in each patient was done 1 day before a coronary angiogram and FIMT was recorded.</p><p><strong>Results: </strong>There was a significant difference (<i>p</i>-value - < 0.001) found in the mean FIMT in patients with normal coronaries (mean FIMT - 0.49 ± 0.05) and patients having CAD (mean FIMT - 0.73 ± 0.17). The area under the receiver operating characteristic (ROC) curve of mean FIMT in predicting abnormal coronaries was 0.903 (95%CI 0.847-0.958, <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>The FIMT has a strong correlation with coronary artery disease. With the help of this non-invasive tool, we can diagnose subclinical atherosclerosis and it may contribute to the prevention of CAD and its severe manifestations.</p><p><strong>Graphical abstract: </strong></p>","PeriodicalId":13285,"journal":{"name":"Indian Journal of Thoracic and Cardiovascular Surgery","volume":"41 3","pages":"264-271"},"PeriodicalIF":0.7000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11833012/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Thoracic and Cardiovascular Surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s12055-024-01824-4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/9/26 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
Background/objective: Atherosclerosis is a systemic multifocal disease which most commonly involves branching points of the large and medium-sized arteries. The carotid intima-media thickness (c-IMT) is an established marker for increased cardiovascular risk and cerebrovascular disease. In this study, we aimed to establish the role of femoral intima-media thickness (FIMT) in predicting cardiovascular risk in angiographically confirmed patients of coronary artery disease (CAD) when compared with apparently healthy patients (having normal coronary angiogram).
Methods: A total of 114 consecutive patients presented at our institute with symptoms of CAD who underwent coronary angiogram were included in the study. After the coronary angiogram, patients were divided into three groups, group A having normal coronary angiogram, group B having CAD with a synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) score of more than 22, and group C having CAD with a SYNTAX score of 22 or less. The Doppler ultrasound of the bilateral femoral artery in each patient was done 1 day before a coronary angiogram and FIMT was recorded.
Results: There was a significant difference (p-value - < 0.001) found in the mean FIMT in patients with normal coronaries (mean FIMT - 0.49 ± 0.05) and patients having CAD (mean FIMT - 0.73 ± 0.17). The area under the receiver operating characteristic (ROC) curve of mean FIMT in predicting abnormal coronaries was 0.903 (95%CI 0.847-0.958, p < 0.001).
Conclusion: The FIMT has a strong correlation with coronary artery disease. With the help of this non-invasive tool, we can diagnose subclinical atherosclerosis and it may contribute to the prevention of CAD and its severe manifestations.
期刊介绍：
The primary aim of the Indian Journal of Thoracic and Cardiovascular Surgery is education. The journal aims to dissipate current clinical practices and developments in the area of cardiovascular and thoracic surgery. This includes information on cardiovascular epidemiology, aetiopathogenesis, clinical manifestation etc. The journal accepts manuscripts from cardiovascular anaesthesia, cardiothoracic and vascular nursing and technology development and new/innovative products.The journal is the official publication of the Indian Association of Cardiovascular and Thoracic Surgeons which has a membership of over 1000 at present.DescriptionThe journal is the official organ of the Indian Association of Cardiovascular-Thoracic Surgeons. It was started in 1982 by Dr. Solomon Victor and ws being published twice a year up to 1996. From 2000 the editorial office moved to Delhi. From 2001 the journal was extended to quarterly and subsequently four issues annually have been printed out at time and regularly without fail. The journal receives manuscripts from members and non-members and cardiovascular surgeons. The manuscripts are peer reviewed by at least two or sometimes three or four reviewers who are on the panel. The manuscript process is now completely online. Funding the journal comes partially from the organization and from revenue generated by subscription and advertisement.
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