Myocarditis and pericarditis during COVID-19 pandemic: a study of the Italian Society of Cardiology.

IF 2.9 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiovascular Medicine Pub Date : 2025-03-01 Epub Date: 2025-02-04 DOI:10.2459/JCM.0000000000001693

Lucia Ilaria Birtolo, Gianluca Di Pietro, Fabrizio D'Ascenzo, Giuditta Cuccuru, Enrico Fabris, Marco Merlo, Alessandro Andreis, Alida Linda Patrizia Caforio, Matteo Cameli, Riccardo Improta, Gianluca Campo, Gaetano Maria De Ferrari, Michele Emdin, Alfredo Ruggero Galassi, Sabino Iliceto, Massimo Imazio, Biancamaria D'Agata Mottolese, Italo Porto, Roberta Montisci, Giuseppina Novo, Daniela Pavan, Carmine Dario Vizza, Viviana Maestrini, Cristina Basso, Pasquale Perrone Filardi, Gianfranco Sinagra, Massimo Mancone

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引用次数: 0

Abstract

Aims: Some studies about myocarditis and pericarditis following COVID-19 vaccination raised concerns worldwide. However, the heterogeneous diagnostic criteria for postvaccination inflammatory heart diseases may result in overestimating incidence rates. The aim of this multicentre Italian registry is to evaluate the impact of COVID-19 vaccines on the incidence of myocarditis and pericarditis in the Italian population.

Methods: Consecutive patients admitted to Italian hospitals for endomyocardial and/or cardiac magnetic resonance proven acute myocarditis and/or pericarditis in the same period (1 June-31 October) of 2019 and 2021 were enrolled, irrespective of the potential association with the COVID-19 vaccines. Acute pericarditis and/or myocarditis were defined as 'vaccine-related' if clinical presentation occurred within 15 days after COVID-19 vaccination, independently of the dose.

Results: There was a comparable incidence rate ratio (IRR) for inflammatory heart diseases in 2019 and 2021 (2019: IRR 0.67 versus 2021: IRR 0.74, P = 0.45). In particular, the IRR did not differ in myocardial involvement (2019: IRR 0.33 versus 2021: IRR 0.33, P = 1) and pericarditis (2019: IRR 0.37 versus 2021: IRR 0.49, P = 0.09) in both periods. Among 125 cases registered in 2021, 32 (25.6%) were 'vaccine-related'. Among those who experienced 'vaccine-related' myocarditis and/or pericarditis, men with age under 40 years were over-represented (53.12%, P = 0.021).

Conclusion: In a nationwide Italian survey comparing pandemic with prepandemic periods, the overall data do not indicate significant concerns about an increased incidence of pericarditis and myocarditis, suggesting that the vaccine is generally well tolerated for these specific conditions.

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意大利心脏病学会登记：COVID-19疫苗不会增加心肌炎和心包炎的发病率。

目的：本研究报道了全球范围内对COVID-19疫苗接种后心肌炎和心包炎的担忧。然而，疫苗接种后炎症性心脏病的异质诊断标准可能导致高估发病率。这项意大利多中心登记的目的是评估COVID-19疫苗对意大利人群心肌炎和心包炎发病率的影响。方法：纳入2019年和2021年同期（6月1日至10月31日）意大利医院因心肌炎和/或心脏磁共振证实的急性心肌炎和/或心包炎的连续患者，无论是否与COVID-19疫苗有潜在关联。急性心包炎和/或心肌炎被定义为“疫苗相关”，如果临床症状发生在COVID-19疫苗接种后15天内，与剂量无关。结果：2019年和2021年炎症性心脏病的发病率比（IRR）相当（2019年：IRR 0.67 vs 2021年：IRR 0.74, P = 0.45）。特别是，两个时期的IRR在心肌受累（2019年：IRR 0.33 vs 2021年：IRR 0.33, P = 1）和心包炎（2019年：IRR 0.37 vs 2021年：IRR 0.49, P = 0.09）方面没有差异。在2021年登记的125例病例中，32例（25.6%）与“疫苗相关”。在经历“疫苗相关”心肌炎和/或心包炎的人群中，年龄在40岁以下的男性比例过高（53.12%,P = 0.021）。结论：在意大利一项比较大流行与大流行前时期的全国性调查中，总体数据并未表明心包炎和心肌炎的发病率增加，这表明该疫苗可被认为对这些特定疾病具有良好的耐受性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cardiovascular Medicine 医学-心血管系统

CiteScore

3.90

自引率

26.70%

发文量

189

审稿时长

6-12 weeks

期刊介绍： Journal of Cardiovascular Medicine is a monthly publication of the Italian Federation of Cardiology. It publishes original research articles, epidemiological studies, new methodological clinical approaches, case reports, design and goals of clinical trials, review articles, points of view, editorials and Images in cardiovascular medicine. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.