Burden of five major types of gastrointestinal cancer in the Eastern Mediterranean Region.

IF 3.3 Q2 GASTROENTEROLOGY & HEPATOLOGY

BMJ Open Gastroenterology Pub Date : 2025-02-19 DOI:10.1136/bmjgast-2024-001577

Saleh A Alessy, Eileen Morgan, Ali S Al-Zahrani, Mariam Zahwe, Heba Fouad, Freddie Bray, Ariana Znaor, Saleh A Alqahtani

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引用次数: 0

Abstract

Objective: We provide an overview of the latest estimates of five gastrointestinal (GI) cancers in the Eastern Mediterranean Region (EMR) countries to guide cancer control policy.

Methods: We extracted the number of cases and deaths for oesophageal, gastric, liver, colorectal and pancreatic cancers from the GLOBOCAN database produced as estimated by the International Agency for Research on Cancer for the year 2022. Age-standardised incidence and mortality rates (ASR) per 100 000 person-years were estimated for the 22 EMR countries, cancer site and sex.

Results: The estimated 173 000 new cancer cases and 139 000 deaths from the five GI cancers corresponded to 22.2% of the incidence and 28.7% of the mortality burden in the EMR. Across all cancers (for both sexes combined), colorectal cancer ranked third (6.9%; ASR 8.9), followed by liver cancer (6.2%; ASR 8.4) in terms of incidence, while liver cancer (9.6%; ASR 8.1) and gastric cancer (6.4%; ASR 5.5) were the third and fourth leading causes of cancer-related mortality in the region, respectively. Marked differences in cancer incidence and mortality rates were observed between the 22 countries, particularly the 10-fold variations seen in liver cancer incidence.

Conclusion: GI cancers currently account for an important fraction of the cancer burden in the EMR; the present analysis seeks to inform tailored decision-making according to the country-specific GI cancer profiles.

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东地中海地区五种主要胃肠道癌症的负担。

目的：我们概述了东地中海地区（EMR）国家五种胃肠道（GI）癌症的最新估计，以指导癌症控制政策。方法：我们从国际癌症研究机构（International Agency for Research on Cancer）估计的2022年GLOBOCAN数据库中提取食管癌、胃癌、肝癌、结直肠癌和胰腺癌的病例和死亡人数。对22个EMR国家、癌症部位和性别的每10万人年年龄标准化发病率和死亡率（ASR）进行了估计。结果：五种胃肠道癌症估计有17.3万新发癌症病例和13.9万死亡病例，对应于EMR中22.2%的发病率和28.7%的死亡负担。在所有癌症（男女加起来）中，结直肠癌排名第三(6.9%；ASR 8.9)，其次是肝癌(6.2%；ASR 8.4)，而肝癌(9.6%；ASR 8.1)和胃癌(6.4%；ASR 5.5)分别是该地区癌症相关死亡的第三和第四大原因。22个国家之间的癌症发病率和死亡率存在显著差异，特别是肝癌发病率相差10倍。结论：胃肠道癌症目前占EMR癌症负担的重要部分；本分析旨在根据国家特定的胃肠道癌症概况为量身定制的决策提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMJ Open Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

5.90

自引率

3.20%

发文量

审稿时长

2 weeks

期刊介绍： BMJ Open Gastroenterology is an online-only, peer-reviewed, open access gastroenterology journal, dedicated to publishing high-quality medical research from all disciplines and therapeutic areas of gastroenterology. It is the open access companion journal of Gut and is co-owned by the British Society of Gastroenterology. The journal publishes all research study types, from study protocols to phase I trials to meta-analyses, including small or specialist studies. Publishing procedures are built around continuous publication, publishing research online as soon as the article is ready.