Rhabdomyolysis in intensive care unit-distinctive clinical indicators and prognosis.

IF 2.3 3区 医学 Q2 ANESTHESIOLOGY
Zhen Wang, Qing Wang, Jinghan Chen, Leiming Cai
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Abstract

Background: Rhabdomyolysis is commonly encountered in intensive care unit (ICU), yet its clinical features and prognostic indicators have not been comprehensively defined. This study aims to identify clinical characteristics and outcomes of ICU patients with rhabdomyolysis, and assess if rhabdomyolysis predicts outcomes.

Methods: This retrospective study investigated patients admitted to the ICU of Shanghai Baoshan District Wusong Central Hospital from 2022 to 2023. Clinical and laboratory indices, along with discharge outcomes, were analyzed.

Results: The study included 151 patients, divided into Control group (CK ≤ 1000 U/L, n = 117) and RML group (CK > 1000 U/L, n = 34) groups. The RML group showed higher proportions of male gender (76.5% vs. 56.4%, p = 0.035), infection (88.2% vs. 68.4%, p = 0.022), muscle weakness (41.2% vs. 13.7%, p = 0.035), and myoglobin > 1000 U/L (55.9% vs. 14.5%, p < 0.001), but lower incidence of malignant tumors (0% vs. 17.9%, p = 0.017). The poor outcome rate (POR, the combined rate of death and cessation of treatment) was significantly higher in the RML group (52.9% vs. 33.3%, p = 0.038). Multivariate logistic regression analysis identified male gender [OR, 1.120-7.147; p = 0.028], sepsis [OR, 1.234-10.949; p = 0.019], and mechanical ventilation [OR, 1.489-8.478; p = 0.004] as independent risk factors for poor outcome in ICU patients. Rhabdomyolysis was not an independent risk factor.

Conclusions: ICU patients with rhabdomyolysis experienced a significantly higher rate of poor outcomes. Male gender, sepsis, and mechanical ventilation were identified as independent risk factors for poor outcomes, while rhabdomyolysis itself was not found to be an independent risk factor. Prospective research is needed to validate these findings in diverse ICU populations.

重症监护室横纹肌溶解:独特的临床指标和预后。
背景:横纹肌溶解是重症监护病房(ICU)的常见病,但其临床特征和预后指标尚未全面定义。本研究旨在确定ICU横纹肌溶解患者的临床特征和预后,并评估横纹肌溶解是否预测预后。方法:对上海市宝山区吴淞中心医院2022 ~ 2023年ICU收治的患者进行回顾性研究。分析临床、实验室指标及出院情况。结果:共纳入151例患者,分为对照组(CK≤1000 U/L, n = 117)和RML组(CK≤1000 U/L, n = 34)。RML组男性比例(76.5% vs. 56.4%, p = 0.035)、感染(88.2% vs. 68.4%, p = 0.022)、肌肉无力(41.2% vs. 13.7%, p = 0.035)、肌红蛋白> 1000 U/L (55.9% vs. 14.5%, p结论:ICU患者横纹肌溶解不良预后率明显高于对照组。男性、脓毒症和机械通气被认为是不良预后的独立危险因素,而横纹肌溶解本身并不是独立危险因素。需要前瞻性研究在不同的ICU人群中验证这些发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BMC Anesthesiology
BMC Anesthesiology ANESTHESIOLOGY-
CiteScore
3.50
自引率
4.50%
发文量
349
审稿时长
>12 weeks
期刊介绍: BMC Anesthesiology is an open access, peer-reviewed journal that considers articles on all aspects of anesthesiology, critical care, perioperative care and pain management, including clinical and experimental research into anesthetic mechanisms, administration and efficacy, technology and monitoring, and associated economic issues.
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