Resveratrol from Peanut Sprout Extract Promotes NK Cell Activation and Antitumor Activity.

IF 3 3区 医学 Q2 PHARMACOLOGY & PHARMACY
Biomolecules & Therapeutics Pub Date : 2025-03-01 Epub Date: 2025-02-20 DOI:10.4062/biomolther.2024.133
Hyunmin Chung, Seong Ho Bak, Eunju Shin, Taeho Park, Jinwoo Kim, Hanseul Jeong, Haiyoung Jung, Suk Ran Yoon, Ji-Yoon Noh
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引用次数: 0

Abstract

Natural killer (NK) cells are innate immune cells that are crucial for anticancer activity and have been developed as an immune cell therapy for leukemia. However, their limited effectiveness against solid tumors has prompted research into methods to enhance NK cell activity through combination therapies. Health supplements capable of boosting immune surveillance against tumor cells are gaining attention owing to their potential benefits. Resveratrol, a stilbenoid produced by several plants including peanuts and grapes, reportedly exerts anticancer effects and can activate immune cells. The peanut sprout extract cultivated with fermented sawdust medium (PSEFS) is rich in resveratrol, leveraging its health benefits in terms of the dry weight of herbal products, thus maximizing the utilization of resveratrol's beneficial properties. Our study compared the efficacy of resveratrol and PSEFS and revealed that PSEFS significantly enhanced NK cell activation compared with an equivalent dose of resveratrol. We investigated the ability of PSEFS to potentiate NK cell anticancer activity, focusing on NK cell survival, tumor cell lysis, and NK cell activation in PSEFS-administered mice. Our findings suggest that PSEFS could be a potential NK cell booster for cancer immunotherapy.

花生芽提取物中的白藜芦醇促进NK细胞活化和抗肿瘤活性。
自然杀伤细胞(NK)是一种先天免疫细胞,具有重要的抗癌活性,已成为白血病的一种免疫细胞疗法。然而,它们对实体肿瘤的有限疗效促使人们研究通过联合治疗提高NK细胞活性的方法。能够增强对肿瘤细胞的免疫监视的保健品由于其潜在的益处而受到关注。据报道,白藜芦醇是一种由花生和葡萄等几种植物产生的二苯乙烯类化合物,具有抗癌作用,可以激活免疫细胞。用发酵木屑培养基(PSEFS)培养的花生芽提取物富含白藜芦醇,在草药产品的干重方面发挥其健康益处,从而最大限度地利用白藜芦醇的有益特性。我们的研究比较了白藜芦醇和PSEFS的功效,发现与同等剂量的白藜芦醇相比,PSEFS显著增强了NK细胞的活化。我们研究了PSEFS增强NK细胞抗癌活性的能力,重点关注给药小鼠的NK细胞存活、肿瘤细胞裂解和NK细胞活化。我们的研究结果表明,PSEFS可能是一种潜在的NK细胞增强剂,用于癌症免疫治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.60
自引率
8.10%
发文量
72
审稿时长
6-12 weeks
期刊介绍: Biomolecules & Therapeutics (Biomolecules & Therapeutics) (Print ISSN 1976-9148, Online ISSN 2005-4483) is an international, peer-reviewed, open access journal that covers pharmacological and toxicological fields related to bioactive molecules and therapeutics. It was launched in 1993 as "The Journal of Applied Pharmacology (ISSN 1225-6110)", and renamed "Biomolecules & Therapeutics" (Biomol Ther: abbreviated form) in 2008 (Volume 16, No. 1). It is published bimonthly in January, March, May, July, September and November. All manuscripts should be creative, informative, and contribute to the development of new drugs. Articles in the following categories are published: review articles and research articles.
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