Photoredox/Copper Dual-Catalyzed Three-Component Perfluoroalkyl Trifluoromethylthiolation of Alkenes.

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-02-20 DOI:10.1021/acs.orglett.5c00289

Kang Guo, Shaomian Liu, Yutong Yang, Fang Xu, Yongchao Lu, Jiayi Shang, Aizhen Song

引用次数: 0

Abstract

A new three-component 1,2-perfluoroalkyl trifluoromethylthiolation of alkenes via dual photoredox/copper catalysis has been established, affording a variety of C_nF_2n+1/CF₃S-containing molecules under mild conditions in a redox-neutral manner. This protocol exhibits excellent functional group tolerance, broad compatibility with various alkenes and perfluoroalkyl iodides, and potential utility in the modification of bioactive molecules.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.