Carbon-based nanomaterials: interactions with cells, brain therapies, and neural sensing

IF 3.4 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY
Lorena Gárate-Vélez, Mildred Quintana
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引用次数: 0

Abstract

Carbon nanomaterials (CNMs) are characterized by their extensive surface area and extraordinary electronic, thermal, and chemical properties, offering an innovative potential for biomedical applications. The physicochemical properties of CNMs can be fine-tuned through chemical functionalization to design the bio-nano interface, allowing for controlled biocompatibility or specific bioactivity. This versatility offers a transformative approach to addressing the inherent limitations of conventional brain therapies, which frequently demonstrate low efficacy and significant adverse effects. This review delves into recent advances in understanding the intricate interactions between carbon nanostructures and cellular systems, highlighting their activity in brain therapy and neuronal sensing. We provide a comprehensive analysis of key nanostructures, including few-layer graphene (FLG), graphene oxide (GO), graphene quantum dots (GQD), single- and multi-walled carbon nanotubes (SWCNT and MWCNT), carbon nanohorns (CNH), carbon nanodiamonds (CNDs), and fullerenes (C60). Their unique atomic configurations and surface modifications are examined, revealing the underlying mechanisms that drive their biomedical applications. This review highlights how a deep understanding of the interactions between CNMs and cells can catalyze innovative neurotherapeutic solutions. By leveraging their unique properties, CNMs address critical challenges such as crossing the blood–brain barrier, improving therapeutic accuracy, and minimizing side effects. These advances have the potential to significantly improve the treatment outcomes of brain disorders, paving the way for a new era of targeted and effective neurological interventions.

碳基纳米材料:与细胞的相互作用、脑疗法和神经传感
碳纳米材料(CNMs)的特点是其广泛的表面积和非凡的电子、热学和化学性质,为生物医学应用提供了创新潜力。cnm的物理化学性质可以通过化学功能化来设计生物纳米界面,从而实现可控的生物相容性或特定的生物活性。这种多功能性为解决传统脑疗法的固有局限性提供了一种变革性的方法,传统脑疗法经常表现出低疗效和显著的不良反应。这篇综述深入研究了碳纳米结构和细胞系统之间复杂相互作用的最新进展,重点介绍了它们在脑治疗和神经元传感中的活动。我们全面分析了关键的纳米结构,包括少层石墨烯(FLG)、氧化石墨烯(GO)、石墨烯量子点(GQD)、单壁和多壁碳纳米管(SWCNT和MWCNT)、碳纳米角(CNH)、碳纳米金刚石(CNDs)和富勒烯(C60)。研究了它们独特的原子构型和表面修饰,揭示了驱动其生物医学应用的潜在机制。这篇综述强调了如何深入了解CNMs和细胞之间的相互作用可以催化创新的神经治疗方案。通过利用其独特的特性,CNMs解决了诸如穿越血脑屏障、提高治疗准确性和最小化副作用等关键挑战。这些进展有可能显著改善脑部疾病的治疗结果,为有针对性和有效的神经干预的新时代铺平道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
8.60
自引率
0.00%
发文量
1
审稿时长
13 weeks
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